Time- and dose-related changes in the white matter of the rat brain after single doses of X rays

The British Journal of Radiology
W CalvoT K Yeung

Abstract

Following the local irradiation of the rat brain with single doses of 17.5-25 Gy of X rays, necrosis of the white matter was seen after a latent interval of greater than 26 weeks. At 39 weeks and 52 weeks after irradiation the incidence of necrosis was dose-related. The doses associated with a 50% incidence of necrosis in the white matter (ED50) at these times were 23.45 +/- 0.49 and 20.98 +/- 0.91 Gy, respectively. At both these times the incidence of necrosis was higher in the fimbria than in the capsula interna and the corpus callosum. This reflects a variation in the latency time for the appearance of necrosis. Necrosis occurs earlier in the fimbria. In the corpus callosum and the capsula interna the latency times for the appearance of necrosis were also dose-dependent. In the latent period prior to the onset of necrosis of the fimbria, a number of dose-related changes were seen in the vasculature and the associated astroglial cells. These changes, which included blood vessel dilation, blood vessel wall thickening, endothelial cell nuclear enlargement and the hypertrophy of perivascular astrocytes, were highly correlated and when combined appeared to represent a "unit of tissue injury". The incidence and severity of this "u...Continue Reading

References

Oct 1, 1979·The British Journal of Radiology·B M Hubbard, J W Hopewell
Oct 1, 1976·Acta Radiologica: Therapy, Physics, Biology·R AdolfssonB Winblad
Nov 1, 1987·The British Journal of Radiology·J W HopewellA Dixon-Brown
Nov 1, 1987·The British Journal of Radiology·W CalvoT K Yeung
Feb 1, 1974·The British Journal of Radiology·J W Hopewell
Jun 1, 1972·The British Journal of Radiology·J W Hopewell, J B Cavanagh
Mar 1, 1970·The British Journal of Radiology·J W Hopewell, E A Wright
Nov 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J F Knowles
Aug 1, 1982·The Journal of Pathology·W F Blakemore, A C Palmer
Jul 1, 1980·The British Journal of Radiology·H S Reinhold, J W Hopewell
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·W ZEMAN
Jan 1, 1962·Journal of Neuropathology and Experimental Neurology·L J RUBINSTEINJ MIQUEL

Citations

Aug 16, 2014·Zeitschrift für medizinische Physik·Falk TillnerWolfgang Enghardt
Sep 11, 2012·Medical Physics·Mohammad-Reza Nazem-ZadehYue Cao
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bradley W SchullerJ A Coderre
Jun 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·F Avraham DilmanianDavid J Anschel
Oct 1, 1988·The British Journal of Radiology·H R Withers, J M Taylor
Oct 1, 1989·The British Journal of Radiology·R H SimmondsM E Robbins
Sep 1, 1992·The British Journal of Radiology·Timothy E Schultheiss, L C Stephens
Feb 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yue CaoTheodore S Lawrence
Feb 22, 2012·Current Neurology and Neuroscience Reports·James FinkMarc C Chamberlain
Nov 1, 2012·Neuro-oncology·Dana Greene-Schloesser, Mike E Robbins
Jan 1, 1996·Acta neurochirurgica·T KamiryoL Steiner
Apr 26, 1996·Neuroscience Letters·M BellinzonaJohn R Fike
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·John R FikeT M Seilhan
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·P A StewartC S Wong
Jun 18, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Judit BenczikJ W Hopewell
May 13, 1998·Behavioural Brain Research·H HodgesM Rezvani
Nov 3, 2005·International Journal of Radiation Biology·K NakayaGlenn T Gobbel
Oct 1, 1992·International Journal of Radiation Biology·E VrdoljakP J Tofilon
Jan 23, 2016·Molecular Neurobiology·Lianhong YangYamei Tang
Jun 25, 2013·International Journal of Radiation Oncology, Biology, Physics·Samuel T ChaoJohn H Suh
Mar 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Jinsoo UhChiaho Hua
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J A CoderreH B Liu
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E H LoJ I Fabrikant
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·Timothy E Schultheiss, L C Stephens
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·D De RuysscherE van der Schueren
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·S H PearlmanD Gash
Dec 5, 2009·Neuroimaging Clinics of North America·Pia C Sundgren, Yue Cao
Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·H S ReinholdA P van der Berg
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·A C RuifrokA J van der Kogel
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·J A CoderreD Gash
May 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M MildenbergerC M Ludgate
Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·E H LoJ I Fabrikant
Jul 25, 2009·Journal of the Neurological Sciences·Lei ShiJudy K Brunso-Bechtold
Aug 30, 2008·International Journal of Radiation Oncology, Biology, Physics·Carol A HahnLawrence B Marks
Sep 18, 2008·Epilepsy & Behavior : E&B·Ramkumar KurubaAshok K Shetty
Mar 7, 2015·Neurologia Medico-chirurgica·Shin-Ichi MiyatakeToshihiko Kuroiwa
May 14, 2008·International Journal of Radiation Oncology, Biology, Physics·Lei ShiJudy K Brunso-Bechtold
Mar 4, 2008·International Journal of Radiation Oncology, Biology, Physics·Vijaya NageshYue Cao
Dec 4, 2015·Medical Physics·Cécile PeucelleYolanda Prezado
Dec 10, 2015·Frontiers in Oncology·F Avraham DilmanianSunil Krishnan
Apr 3, 2007·Neuroscience Letters·Pragathi AchantaJoe L Martinez
Mar 31, 2007·Seminars in Radiation Oncology·Elizabeth S EvansLawrence B Marks
Jan 25, 2007·Neurosurgery Clinics of North America·John R FikeCharles L Limoli
Apr 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·Kevin C ChanEd X Wu
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Z FuksA Haimovitz-Friedman
Apr 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Robert A Nordal, C Shun Wong
Mar 10, 2004·Hematology/oncology Clinics of North America·Maria Werner-WasikTimothy E Schultheiss
Jan 23, 2013·Neurological Research·Alexander SemmlerMichael Linnebank
Oct 31, 2013·International Journal of Radiation Biology·Paola Ballesteros-ZebaduaCarlos Paz
Feb 13, 2010·International Journal of Radiation Biology·Won Hee LeeYong Woo Lee
Mar 21, 2015·Neurobiology of Learning and Memory·Yeonghoon SonChangjong Moon
Apr 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Silun WangJinyuan Zhou
Nov 14, 2014·PloS One·Nikolett SándorHargita Hegyesi
Sep 20, 2016·Radiation Research·Nong YangXiaorong Dong
Dec 17, 2016·Nature Reviews. Neurology·Milan T MakaleSantosh Kesari
Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y SarriR Gomis
Oct 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C S ChiangH R Withers
Aug 10, 1999·Journal of Magnetic Resonance Imaging : JMRI·Y L ChanG Cao
Sep 11, 2016·Practical Neurology·Marina Milic, Jeremy H Rees
Mar 6, 2018·International Journal of Radiation Biology·Masoud NajafiHamid Abdollahi
Feb 12, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·S Okada, R Okeda
Aug 6, 2002·Nature Medicine·Michelle L MonjeTheo D Palmer
Dec 21, 2004·Journal of Korean Medical Science·Joo Han KimHoon Kap Lee
Oct 22, 2005·Radiation Research·William R BrownKenneth T Wheeler
May 8, 2000·Radiation Research·P J Tofilon, John R Fike
Jul 17, 2003·The Neurologist·Pierre Giglio, Mark R Gilbert
Oct 1, 1988·The British Journal of Radiology·M C Berenbaum
Oct 23, 2004·Stereotactic and Functional Neurosurgery·James D RabinovR Gilberto Gonzalez
Jan 9, 2019·Frontiers in Neuroscience·Eliedonna CacaoFrancis A Cucinotta
May 22, 2010·Journal of Neuro-oncology·L R RogersR Jain
Aug 1, 1992·Neurosurgery·D KondziolkaJ C Flickinger
Sep 20, 2002·Journal of Radiation Research·Sentaro TakahashiKumie Nojima
May 7, 2015·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A K PiskunovA A Potapov
Oct 17, 2018·Frontiers in Oncology·Balamurugan VellayappanArjun Sahgal
Jul 1, 2020·Current Neurology and Neuroscience Reports·Rifaquat RahmanPatrick Y Wen
Jul 23, 2020·Dose-response : a Publication of International Hormesis Society·Nahida SultanaBing Wang
Mar 26, 2010·Radiation Research·Xiao Wen MaoGregory A Nelson
Jan 8, 2000·Neurosurgery·M M O'Connor, M R Mayberg
Nov 17, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julie ConstanzoMartin Lepage
May 18, 2020·Stem Cell Reviews and Reports·Chengyan ChuShen Li
Jul 11, 1998·Medical and Pediatric Oncology·J W Hopewell
Apr 1, 2000·Journal of Neuropathology and Experimental Neurology·T AzizA Chanana
Jun 17, 2004·Journal of Neuropathology and Experimental Neurology·Robert A Nordal, C Shun Wong
Feb 6, 2020·Clinical and Translational Radiation Oncology·Florent GuilleminGuillaume Dupic
Apr 3, 2021·Cancers·Katharina WitzmannEsther G C Troost
Apr 27, 2021·Physics and Imaging in Radiation Oncology·Laura BurgessShawn Malone

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Brain
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Radiation Injuries, Experimental
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