Time- and dose-response effects of the mycotoxin, fumonisin B(1) on sphingoid base elevations in precision-cut rat liver and kidney slices

Toxicology in Vitro : an International Journal Published in Association with BIBRA
W P NorredK A Voss

Abstract

Fumonisins are mycotoxins produced on corn (Zea mays) by the common fungus Fusarium moniliforme. The fumonisins are potent inhibitors of sphingolipid biosynthesis and cause dramatic elevations in the free sphingoid base, sphinganine, both in cells in culture and in urine, blood and tissues of animals dosed with the toxins. In this study the effects of fumonisin B(1) (FB(1)) on sphingoid bases in precision-cut rat liver and kidney slices were evaluated. In liver slices exposed for 20 hr to FB(1), as little as 0.1 muM caused a 40-fold elevation in free sphinganine. Kidney slices were less responsive, and a 1 muM dose of FB(1) was required to cause a 10-fold increase in sphinganine. The amount of sphinganine in liver slices exposed to FB(1) increased in a time-dependent manner over a 72-hr period, but kidney slices exposed to the same doses of FB(1) showed a peak elevation of sphinganine after 24 hr, with a decline in the levels over the next 48 hr. Liver slices may more closely approximate the in vivo response of animals to FB, than do primary hepatocytes (in which sphinganine may be elevated > 100-fold), because the elevations in sphinganine were similar to those reported in livers of animals fed fumonisins. On the other hand, t...Continue Reading

References

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Citations

Aug 10, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E N EnongeneR T Riley
Aug 31, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W P NorredR D Plattner
Aug 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K S McKenzieT D Phillips
Nov 25, 2000·Toxicology·C Lerche-Langrand, H J Toutain
Jul 1, 2002·Environmental Toxicology and Pharmacology·Arno C GutlebAlbertinka J Murk
Mar 1, 1998·Environmental Toxicology and Pharmacology·K A VossW P Norred
Nov 4, 2005·Progress in Lipid Research·J M SorianoA I Catalá
Jan 14, 2009·Journal of Animal Physiology and Animal Nutrition·E O Ewuola
Apr 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ronald T Riley, Kenneth A Voss

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