Time above 1500 copies: a viral load measure for assessing transmission risk of HIV-positive patients in care

AIDS
Gary MarksThomas P Giordano

Abstract

We examined HIV transmission potential of patients in care by analyzing the amount of person-time spent above a viral load threshold that increases risk for transmission. Observational cohort and supplemental data. The cohort included HIV patients who received care at six HIV clinics in the United States, from 1 April 2009 to 31 March 2013, and had two or more viral load tests during this interval. Person-time (in days) above a viral load of 1500 copies/ml out of the total observation time was determined by inspecting consecutive pairs of viral load results and the time intervals between those pairs. The person-time rate ratios comparing demographic and clinical subgroups were estimated with Poisson regression. The cohort included 14 532 patients observed for a median of 1073 days with a median of nine viral load records. Ninety percent of the patients had been prescribed antiretroviral therapy. On average, viral load exceeded 1500 copies/ml during 23% of the patients' observation time (average of 84 days per year, per patient). Percentage of person-time above the threshold was higher among patients who had more than a fourth of their viral load pairs exceeding a 6-month interval (34% of observation time), patients not on antir...Continue Reading

References

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Citations

Jan 1, 2015·Nature Reviews. Disease Primers·Steven G DeeksSusan Buchbinder
Apr 20, 2016·Global Public Health·David HoosKarl-Lorenz Dehne
Jul 1, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicole CrepazH Irene Hall
Oct 7, 2016·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Charitha GowdaRobert Gross
Mar 7, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Preeti PathelaDenis Nash
Jun 30, 2018·AIDS·Maria C B MendozaUNKNOWN HIV Outpatient Study Investigators
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May 24, 2016·AIDS Patient Care and STDs·Parya SaberiMarguerita Lightfoot
Feb 21, 2019·Journal of the International Association of Providers of AIDS Care·Seth Charles KalichmanDominica Hernandez
Apr 8, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Seth KalichmanKatherine R Thorson
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Apr 7, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert H PaulBeau M Ances
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Jun 24, 2021·Medicine·Frank J PalellaUNKNOWN HIV Outpatient Study (HOPS)
Jun 29, 2021·Analytical Chemistry·Christopher P MancusoMichael Springer

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