PMID: 6161539Jan 1, 1981Paper

Time and dose dependencies for priming effect of glucose on insulin secretion

The American Journal of Physiology
V Grill

Abstract

Short-term exposure to glucose increases insulin secretion during subsequent stimulation. This priming effect of glucose was further investigated in the perfused rat pancreas. A 5-min pulse of 27.7 mM glucose enhanced the response to a second pulse of the sugar after a 5- or 30-min period of 3.9 mM glucose. With a 10-min pulse of 27.7 mM glucose, the priming effect tended to persist also after a 60-min but not after a 90-min rest period. The priming effects of glucose were also evaluated from enhancement of stimulation 15 min later with 3-isobutyl-l-methylxanthine (IBMX). A 10-min pulse of 8.3 and 27.7, but not 5.6 mM glucose enhanced IBMX-induced insulin secretion. Cycloheximide did not abolish the priming effect of glucose on IBMX-induced insulin secretion. Conclusions are 1) priming is rapidly induced; 2) it persists longer than the time of induction; 3) threshold concentrations of glucose that induce priming are similar to those that initiate insulin secretions; and 4) mechanisms causing priming may not involve protein synthesis.

References

Nov 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P VagueF Mahmoud
Oct 1, 1976·Endocrinology·D L King, W L Chick
Jan 1, 1972·Diabetes·F M MatschinskyJ Kotler-Brajtburg
Sep 1, 1969·Canadian Journal of Physiology and Pharmacology·B J Lin, R E Haist
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher

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Citations

Aug 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philippe G Cammisotto, Ludwik J Bukowiecki
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·S FujimotoY Seino
Oct 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·Subhadra C GunawardanaGeoffrey W G Sharp
Apr 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Subhadra C GunawardanaDavid W Piston

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