Time and dose study on the response of rats to the hypolipidaemic drug fenofibrate

Toxicology
S C PriceJ W Bridges

Abstract

Groups of male Wistar albino rats were administered diets containing sufficient fenofibrate to ensure intakes of either 200, 60 or 13 mg/kg/day or sufficient clofibrate to ensure an intake of 400 mg/kg/day. Four rats from each experimental group and 6 control rats were killed, 3, 7, 14 and 28 days, 8, 12 and 20 weeks and 6, 9, 12 and 18 months after commencement of treatment. At all time points livers were subjected to histological, electron microscopic and biochemical examination, the other major abdominal organs were removed for histological examination. A more extensive necropsy was carried out on rats killed after 12 and 18 months. The major alterations were observed in the liver, although there were also morphological changes in the thyroid, pancreas and kidney after prolonged treatment. The hepatic changes followed a distinct time course. Within 24 h of offering diets containing the compounds to the rats there was accumulation of small droplets of lipid, induction of peroxisomal enzymes and of the specific cytochrome P-450 catalysing omega-hydroxylation of fatty acids and an increase in the number of mitotic figures. More slowly developing changes were loss from the centrilobular zone of fat, glycogen and of glucose 6-pho...Continue Reading

References

Aug 1, 1978·Toxicology and Applied Pharmacology·D E Moody, J K Reddy
Jul 1, 1978·Acta Pathologica Japonica·T Takizawa, S Hatakeyama
Dec 1, 1985·Toxicology and Applied Pharmacology·F E MitchellJ W Bridges
Jul 15, 1983·Biochemical Pharmacology·D M CapuzziD M Scott

❮ Previous
Next ❯

Citations

Dec 1, 1992·Biological Trace Element Research·S GhoshG Talukder
Apr 20, 2005·Archives of Toxicology·Jane DelaneyCatherine J Waterfield
May 1, 1994·The International Journal of Biochemistry·J ChandogaG Hocman
Jun 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R S AhmedR H Hinton
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P BentleyH J Wiegand
Mar 1, 1992·General Pharmacology·E Kunec-VajićD Muacević-Katanec
Dec 27, 1996·Annals of the New York Academy of Sciences·V NilakantanH P Glauert
Dec 1, 1986·Environmental Health Perspectives·R H HintonJ W Bridges
Feb 8, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Stewart J WilkinsAlbena Ivanisevic
Mar 5, 1999·Drug Metabolism Reviews·M L RoseR G Thurman
Mar 4, 2005·Critical Reviews in Toxicology·Michelle L O'BrienHoward P Glauert
Aug 29, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·David HautonStuart Egginton
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Yuichi HaranoTakeshi Okanoue
Jun 1, 1988·Regulatory Toxicology and Pharmacology : RTP·W T Stott
Nov 9, 2000·Regulatory Toxicology and Pharmacology : RTP·B Silva Lima, J W Van der Laan
Oct 13, 2006·FEMS Immunology and Medical Microbiology·Claudia BalaguéAna María Evangelista De Duffard
Mar 23, 2010·Toxicologic Pathology·Jeffrey A KramerAlan G E Wilson
Feb 15, 1997·Microscopy Research and Technique·P SchneiderU Busch
Oct 30, 2018·Toxicological Research·Shoji FukushimaMichiharu Matsumoto
Aug 1, 1987·Environmental Health Perspectives·L ZeiseE A Crouch
Feb 19, 2021·Cellular and Molecular Gastroenterology and Hepatology·Mirco GlitscherEberhard Hildt
Dec 30, 1988·Biochemical and Biophysical Research Communications·P I Eacho, P S Foxworthy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.