Time, change and peptic ulcer disease in Rotherham, UK

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
K D Bardhan, C Royston

Abstract

We have documented the changing pattern of peptic ulcer disease in our centre in the last quarter of the 20th century and speculate on the reasons thereof. The profile of peptic ulcer disease patients presenting newly to our centre (population 250,000) from 1977 to 2001 was examined. All patients were prospectively followed and detailed records kept. Results are presented in 5-year periods. Seven thousand five hundred and ninety new peptic ulcer disease patients (5564 duodenal ulcer+2026 gastric ulcer) were seen, peaking in 1982-1986 but declining thereafter, and with a falling male preponderance. Patients with gastric ulcer were older than those with duodenal ulcer; were older than duodenal ulcer, the mean age of both increased over time and the age gap from the general population widened. The numbers presenting with perforation changed little but haemorrhage increased, particularly amongst the elderly. Ulcers refractory to H2 receptor antagonists declined even before proton pump inhibitors were introduced. Elective surgery, already declining before H2 receptor antagonists, had virtually disappeared by 1992-1996. Peptic ulcer disease affects an older population, an increasing proportion of whom present with haemorrhage. Refrac...Continue Reading

References

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Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K D BardhanC Royston
Oct 6, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K D BardhanC Lyon
Nov 22, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K D BardhanA K Nayyar

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Citations

Sep 6, 2011·The Surgical Clinics of North America·John S Bolton, W Charles Conway
Nov 28, 2009·Best Practice & Research. Clinical Gastroenterology·Marilisa FranceschiAlberto Pilotto
May 19, 2009·Gastroenterology Clinics of North America·Rupert W Leong
Jan 6, 2011·Alimentary Pharmacology & Therapeutics·A LanasX Calvet
Jan 28, 2014·Alimentary Pharmacology & Therapeutics·H MalmiM A Färkkilä
Jun 19, 2010·Orvosi hetilap·Krisztina Hagymási, Zsolt Tulassay
Feb 28, 2018·Frontline Gastroenterology·Hey-Long ChingMark E McAlindon
Mar 7, 2020·Current Problems in Surgery·Alice WangTheodore N Pappas

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