Time Course and Association of Functional and Biochemical Markers in Severe Semitendinosus Damage Following Intensive Eccentric Leg Curls: Differences between and within Subjects

Frontiers in Physiology
Gerard CarmonaJoan A Cadefau

Abstract

Purpose: To investigate the extent and evolution of hamstring muscle damage caused by an intensive bout of eccentric leg curls (ELCs) by (1) assessing the time course and association of different indirect markers of muscle damage such as changes in the force-generating capacity (FGC), functional magnetic resonance (fMRI), and serum muscle enzyme levels and (2) analyzing differences in the degree of hamstring muscle damage between and within subjects (limb-to-limb comparison).Methods:Thirteen male participants performed six sets of 10 repetitions of an ELC with each leg. Before and at regular intervals over 7 days after the exercise, FGC was measured with maximal isometric voluntary contraction (MVC). Serum enzyme levels, fMRI transverse relaxation time (T2) and perceived muscle soreness were also assessed and compared against the FGC.Results:Two groups of subjects were identified according to the extent of hamstring muscle damage based on decreased FGC and increased serum enzyme levels: high responders (n= 10, severe muscle damage) and moderate responders (n= 3, moderate muscle damage). In the high responders, fMRI T2 analysis revealed that the semitendinosus (ST) muscle suffered severe damage in the three regions measured (pro...Continue Reading

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Citations

Sep 25, 2018·Frontiers in Physiology·Víctor Illera-DomínguezJoan A Cadefau
Oct 4, 2020·Medicine and Science in Sports and Exercise·Sumiaki MaeoTadao Isaka
Sep 25, 2021·The British Journal of Radiology·Anne SchomöllerFrank Mayer

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