Myocardial cationic electrolytes were determined at regular time intervals up to 24 hours after coronary artery ligation in the dog. Replicate electrolyte ratios were computed for different areas of the heart at each time interval. For purposes of statistical analysis, ratios from two border areas and four areas remote from the infarct were pooled as values for ZONE B and ZONE N, respectively, and compared with those from the infarct proper, ZONE I. Ischemia-induced tissue Mg++/Ca++ changes paralleled those of K+/Na+ with respect to time course and zonal variations. In ZONE I, both K+/Na+ and Mg++/Ca++ fell precipitously during the first hour, and the falls became more gradual thereafter, approac hing those of extracellular fluid at 24 hours. Changes in ZONE B, which appeared normal histologically, followed a similar downward trend but differed in magnitude from those in ZONE I (P smaller than 0.01). Changes in ZONE N were small but did not always overlap values in sham-operated dogs. It was concluded that lowered tissue K+/Na+ and Mg++/Ca++ were sensitive, but not specific, indices of myocardial ishemia, and multiple samplings of ionic ratios were essential for proper interpretation of ischemia-induced myocardial electrolyte d...Continue Reading
Expansion of extracellular space in the nonischemic zone of the infarcted heart and concomitant changes in tissue electrolyte contents in the rat
Myocardial electrolyte derangement: crucial feature of pluricausal, so-called coronary, heart disease (dysionic cardiopathy)
Ventricular arrhythmias and K+ transfer during myocardial ischemia and intervention with procaine amide, insulin, or glucose solution
Excitatory factors in ventricular tachycardia resulting from myocardial ischemia; potassium a major excitant
Evidence that serum potassium is not the etiological agent in ventricular fibrillation following coronary artery occlusion
Effects of histamine and potassium release agents on ventricular rhythms before and after coronary occlusion
Nuclear morphometry of the myocardial cells as a diagnostic tool in cases of sudden death due to coronary thrombosis
Dissociation between regional myocardial dysfunction and subendocardial ST segment elevation during and after exercise-induced ischemia in dogs
Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.
A double blind placebo controlled study of early and late administration of recombinant tissue plasminogen activator in acute myocardial infarction
Significance of reciprocal S-T segment depression in anterior precordial leads in acute inferior myocardial infarction: concomitant left anterior descending coronary artery disease?
Effect of changes in perfusion pressure on the position of the electrophysiologic border zone in acute regional ischemia in isolated perfused dog and pig hearts
The potassium/sodium ratio in the demonstration of sudden ischemic cardiac death: a critical appraisal
Grape seed proanthocyanidins ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes: an in vivo study
Association between ion shift index and prognosis in severe trauma patients without isolated head injury.
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