Time course and zonal variations of ischemia-induced myocardial cationic electrolyte derangements

J T LieJ L Titus


Myocardial cationic electrolytes were determined at regular time intervals up to 24 hours after coronary artery ligation in the dog. Replicate electrolyte ratios were computed for different areas of the heart at each time interval. For purposes of statistical analysis, ratios from two border areas and four areas remote from the infarct were pooled as values for ZONE B and ZONE N, respectively, and compared with those from the infarct proper, ZONE I. Ischemia-induced tissue Mg++/Ca++ changes paralleled those of K+/Na+ with respect to time course and zonal variations. In ZONE I, both K+/Na+ and Mg++/Ca++ fell precipitously during the first hour, and the falls became more gradual thereafter, approac hing those of extracellular fluid at 24 hours. Changes in ZONE B, which appeared normal histologically, followed a similar downward trend but differed in magnitude from those in ZONE I (P smaller than 0.01). Changes in ZONE N were small but did not always overlap values in sham-operated dogs. It was concluded that lowered tissue K+/Na+ and Mg++/Ca++ were sensitive, but not specific, indices of myocardial ishemia, and multiple samplings of ionic ratios were essential for proper interpretation of ischemia-induced myocardial electrolyte d...Continue Reading


Apr 1, 1970·Journal of Clinical Pathology·J G McVie
Oct 5, 1973·Circulation Research·P I Polimeni, E Page
Feb 1, 1972·The American Journal of Cardiology·T W LangS Meerbaum
Oct 1, 1972·The American Journal of Cardiology·M A Ricciutti
Oct 23, 1971·British Medical Journal·P Taggart, J D Slater
Dec 15, 1971·Experientia·G RecordatiA M Brown
Jan 1, 1971·Cardiology·R B Case
Jan 31, 1969·Annals of the New York Academy of Sciences·D Lehr
Dec 1, 1969·The American Journal of Cardiology·R B Jennings
Dec 1, 1969·The American Journal of Cardiology·R B CaseR S Crampton
Sep 1, 1957·Circulation Research·A CHERBAKOFFW F HAMILTON
May 20, 1959·The Journal of General Physiology·P ELSBACH, I L SCHWARTZ
Aug 1, 1963·The Journal of Experimental Medicine·J G HIRSCHG WEISSMANN
May 1, 1964·Biological Reviews of the Cambridge Philosophical Society·J D JUDAH, K AHMED

❮ Previous
Next ❯


Aug 1, 1979·European Journal of Pharmacology·D D Ku, B R Lucchesi
Jun 3, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James E UdelsonVasken Dilsizian
Dec 17, 1998·Forensic Science International : Synergy·G A LazarosG S Delides
Dec 6, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Brock M TiceNatalia Trayanova
Jun 21, 2011·Journal of Pharmacological and Toxicological Methods·Cristian T BadeaG Allan Johnson
Jul 1, 1977·The American Journal of Cardiology·R P Holland, H Brooks
Jun 1, 1981·The American Journal of Cardiology·D J Hearse, D M Yellon
Jul 1, 1990·Progress in Cardiovascular Diseases·P Anversa, E H Sonnenblick
Sep 1, 1977·Progress in Cardiovascular Diseases·B L Zaret
Oct 1, 1987·The Journal of Surgical Research·S Y SiouffiS F Khuri
Jun 14, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Sara M WeisAndrew D McCulloch
Jun 6, 2009·Journal of Pharmacological and Toxicological Methods·Armando Pérez de PradoFelipe Fernández-Vázquez
Jan 1, 1990·Medicine, Science, and the Law·L M al-Alousi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.