Time-course changes in clinical features of early-onset Japanese type 1 and type 2 diabetes: TWMU hospital-based study

Diabetes Research and Clinical Practice
Yasuko UchigataYasuhiko Iwamoto

Abstract

Using a database of patients with type 1 (n=1675) and type 2 (n=2259) diabetes diagnosed before the age of 30 years at the Diabetes Center, Tokyo Women's Medical University (TWMU), in which such Japanese patients have been registered at the time of first visit since the 1960s, we performed a hospital-based study over the last 40 years to clarify time-course changes in clinical features of type 1 and type 2 diabetes diagnosed before the age of 30 years. Type 2 diabetes had a male dominancy, while there has been a female dominancy in patients with type 1 diabetes as in previous reports of Japanese childhood-onset type 1 diabetes. Such dominances had been continued over the last 40 years. The number of patients with type 2 diabetes and with a past history of obesity increased with time. The age at which type 2 diabetes was diagnosed was suggested to have been getting lower with time, whereas that of type 1 diabetes has been higher with time. There was no marked difference in family history of diabetes in the first-degree relatives of patients with type 2 diabetes, regardless of the presence or absence of a past history of obesity. More female patients with type 2 diabetes diagnosed before the age of 15 years had mothers with type ...Continue Reading

References

Nov 1, 1990·Diabetes Research and Clinical Practice·T OtaniY Hirata
Feb 5, 1987·The New England Journal of Medicine·W E WinterR P Spillar
Apr 1, 1997·Pediatric Clinics of North America·N S Glaser
Feb 28, 2002·Archives of Disease in Childhood·A J DrakeJ P H Shield
Aug 29, 2006·Diabetes Care·Tatsuhiko UrakamiTeruo Kitagawa
May 1, 2007·Diabetes Care·Yohei OgawaYasuhiko Iwamoto

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Citations

May 1, 2009·Diabetes/metabolism Research and Reviews
Jun 4, 2015·Diabetes Research and Clinical Practice·Toshika OtaniYasuko Uchigata
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Ichiro HorieAtsushi Kawakami
Dec 11, 2021·Journal of Diabetes Investigation·Prapai DejkhamronUNKNOWN Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN)

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