Time-course changes in muscle protein degradation in heat-stressed chickens: Possible involvement of corticosterone and mitochondrial reactive oxygen species generation in induction of the ubiquitin-proteasome system

General and Comparative Endocrinology
Kyohei FurukawaM Toyomizu

Abstract

Heat stress (HS) induces muscle protein degradation as well as production of mitochondrial reactive oxygen species (ROS). In the present study, to improve our understanding of how protein degradation is induced by HS treatment in birds, a time course analysis of changes in the circulating levels of glucocorticoid and N(τ)-methylhistidine, muscle proteolysis-related gene expression, and mitochondrial ROS generation, was conducted. At 25 days of age, chickens were exposed to HS conditions (33 °C) for 0, 0.5, 1 or 3 days. While no alteration in plasma N(τ)-methylhistidine concentration relative to that of the control group was observed in the 0.5 day HS group, the concentration was significantly higher in the 3-d HS treatment group. Plasma corticosterone concentrations increased in response to 0.5-d HS treatment, but subsequently returned to near-normal values. HS treatment for 0.5 days did not change the levels of μ-calpain, cathepsin B, or proteasome C2 subunit mRNA, but increased the levels of mRNA encoding atrogin-1 (P<0.05) and its transcription factor, forkhead box O3 (P=0.09). Under these hyperthermic conditions, mitochondrial superoxide production was significantly increased than that of thermoneutral control. Here, we sho...Continue Reading

References

Jan 15, 1996·The Journal of Clinical Investigation·G TiaoP O Hasselgren
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Curtis J WrayPer-Olof Hasselgren
Oct 15, 2003·Free Radical Biology & Medicine·Satomi MiwaMartin D Brand
Dec 8, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·H LinJ Buyse
Dec 8, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·H LinJ Buyse
Oct 14, 2006·Endocrinology·H GilsonJ P Thissen
Jan 9, 2010·Bioscience, Biotechnology, and Biochemistry·Tomomi KamizonoKunioki Hayashi
Jan 13, 2010·Experimental Gerontology·Martin D Brand
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin ZhengS Russ Price
Jul 14, 2010·Antioxidants & Redox Signaling·Peter Storz
Jul 14, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S Boussaid-Om EzzineS Tesseraud
Jul 13, 2011·The Journal of Cell Biology·Toren Finkel
Sep 24, 2011·American Journal of Physiology. Cell Physiology·Laura A A GilliamMichael B Reid
May 15, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·V M TangJ-F Wang
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·O SchakmanJ P Thissen
Sep 4, 2013·Biochimica Et Biophysica Acta·Tomáš MráčekJosef Houštěk
Nov 5, 2013·Antioxidants & Redox Signaling·Mashrur RahmanSabah N A Hussain
Aug 19, 2015·Animal Science Journal = Nihon Chikusan Gakkaihō·Kazuki NakashimaAkira Ohtsuka

❮ Previous
Next ❯

Citations

Nov 22, 2017·Redox Report : Communications in Free Radical Research·Hongchao JiaoHai Lin
Jan 17, 2020·Journal of Applied Physiology·Gerald S SupinskiLeigh Ann P Callahan
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Xin LiLi Chen
Jun 13, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mingming JinGang Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.