Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum

Journal of Medical Virology
Takuji KumagaiY Asano

Abstract

The time-course of cell-mediated immunity in exanthema subitum is not well documented. The lymphoproliferative response to purified human herpesvirus 6 (HHV-6) antigen and to phytohemagglutinin was measured and natural killer (NK) cell activities determined in three consecutive specimens obtained biweekly from 18 young children and infants with exanthema subitum. Virus isolation and PCR detection of virus DNA and determination of neutralization antibody to HHV-6 and -7 were also carried out. The magnitude of the HHV-6 specific lymphoproliferative response varied; however, in most cases the time course kinetics revealed a low response in the acute phase with a subsequent gradual increase. In contrast, NK cell activities were high in the acute phase and declined gradually during convalescence. The lymphoproliferative response to phytohemagglutinin did not show a consistent trend in kinetics of time; however, dynamic changes in activity were observed in patients during the acute and convalescent periods. The results suggest that NK cells play a major role in resolving acute phase infection while specific lymphocyte activity develops later. The cause of the delayed development of HHV-6 specific lymphoproliferative response is unkno...Continue Reading

References

Nov 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z N BernemanR C Gallo
May 1, 1992·The Pediatric Infectious Disease Journal·K TakahashiK Yamanishi
Jan 1, 1991·Microbiology and Immunology·Y YakushijinY Kobayashi
Mar 1, 1990·Transplantation·T OkunoK Tanaka
Apr 1, 1989·The Journal of Pediatrics·Y AsanoS Yoshida
Jun 1, 1993·The Journal of Infectious Diseases·R T HorvatB Chandran
May 1, 1997·Journal of Virology·Y InoueS Fujita
Dec 31, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M YadavB Y Hashim
Jun 22, 1999·The Journal of Experimental Medicine·A GobbiJ M McCune
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·D V AblashiJ E Whitman
Jul 27, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·T AbeY Asano
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa L PrecopioKatherine Luzuriaga
Jun 28, 2003·Blood·Alison SmithPaolo Lusso
Jul 15, 2003·Journal of Virology·Jean-Charles GrivelPaolo Lusso
Aug 17, 2004·Vaccine·Takuji KumagaiHitoshi Kamiya

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Citations

Feb 24, 2012·Journal of Virology·Maria-D NastkeJ Mauricio Calvo-Calle
Jul 11, 2018·Frontiers in Immunology·Derek J HansonDavid M Koelle

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