Time course-dependent evolution of nitric oxide-mediated arterial hyporeactivity to phenylephrine in rats with ligated bile duct

Scandinavian Journal of Gastroenterology
M KimpelE Hanisch

Abstract

Nitric oxide (NO) may be heavily involved the phenomenon of arterial vasodilation in cirrhosis. However, the subject is still controversial. This study therefore characterizes the dynamic role of the NO system during development of experimental cirrhosis. The contractile response to phenylephrine of thoracic rat aortic rings was studied in vitro before and after nitric oxide blockade. Experiments were performed 1, 2, 3, and 4 weeks after induction of cirrhosis via bile duct ligation with an appropriate control group. In bile duct-ligated rats reduction of the maximum contractile response to phenylephrine was 4.4 +/- 7.3% after 1 week, 22.7 +/- 8.7% after 2 weeks, 48.4 +/- 8.3% after 3 weeks, and 64.6 +/- 8.9% after 4 weeks, in comparison with the control group. This reduction in contractility to phenylephrine was completely reversed by blocking NO synthesis. The data presented indicate a dynamic decrease in contractile response to phenylephrine even at an early stage of secondary cirrhosis. Reversibility of the effect after NO synthesis blockade suggests that increased NO synthesis is a major factor in vascular hyporeactivity to vasoconstrictors in cirrhosis.

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SogniD Lebrec
Jul 1, 1992·Gastroenterology·H TilgC Huber
Mar 30, 1991·Lancet·P Vallance, S Moncada
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ClàriaJ Rodés
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A BomzonL M Blendis
Dec 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ClàriaJ Rodés
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NiederbergerR W Schrier

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Citations

Apr 13, 2006·World Journal of Gastroenterology : WJG·Shinya SakuraiHiroshi Fukui
May 10, 2008·Digestive Diseases and Sciences·Mohammad R EbrahimkhaniAhmad R Dehpour
Feb 16, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·P TuncyurekS Ersin

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