Time-course evaluation and treatment of skin inflammatory immune response after ultraviolet B irradiation

Cytokine
Mariela L PazDaniel H Gonzalez Maglio

Abstract

Skin exposure to high doses of ultraviolet B (UVB) radiation generates a severe inflammatory skin response. In the present study we aim to investigate, using in vitro and in vivo models, the time-course of the inflammatory skin immune response after an acute exposure to UVB irradiation, as well as its modulation by a topical non-steroidal anti-inflammatory drug (NSAID) treatment, naproxen. PGE2 production and TNF-alpha levels increase in a post-irradiation time-dependent manner both in vivo and in vitro. This production pattern is also reflected in the iNOS expression levels in vivo and in the IL-6 levels in vitro. Changes observed in these mediators are correlated with histological alterations and dermal infiltration after the acute UVB irradiation. Naproxen treatment notably reduces PGE2 production and iNOS expression, reflecting the COX-NOS crosstalk already reported, although it causes an important increment in TNF-alpha synthesis in the epidermis of irradiated mice. Taken together, our data indicates that the epidermis is severely damaged by UVB radiation but then it is able to fully recover, and that the immune response is modulated by the NSAID treatment, since it is able to reduce the levels of some mediators as well as...Continue Reading

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Citations

May 21, 2011·Journal of Toxicology and Environmental Health. Part a·Federico S WeillDaniel H Gonzalez Maglio
Oct 23, 2009·Photochemistry and Photobiology·Daniel H González MaglioJuliana Leoni
Jul 8, 2011·Science Translational Medicine·John M DawesStephen B McMahon
Jun 4, 2014·Journal of Dermatological Science·Pi-Ling ChangKang-Jey Ho
Aug 19, 2015·Journal of Cellular Physiology·Amiram RavidRuth Koren
Nov 13, 2010·Trends in Immunology·Julia LewisMichael Girardi
May 4, 2013·The Journal of Investigative Dermatology·Yeonsue JangSang W Son
Sep 22, 2015·Journal of Ethnopharmacology·Narisara TiraravesitJarupa Viyoch
Aug 10, 2011·Experimental Dermatology·Daniel H González MaglioJuliana Leoni
Nov 5, 2014·Photodermatology, Photoimmunology & Photomedicine·Eliana M CelaDaniel H Gonzalez Maglio
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Nov 9, 2018·Frontiers in Immunology·Sonya J WolfJ Michelle Kahlenberg
Mar 17, 2021·Acta Physiologica·Cameron R Moattari, Richard D Granstein

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