Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy

Epilepsy & Behavior : E&B
Mark William LopesRodrigo Bainy Leal

Abstract

Epilepsy is a brain function disorder characterized by unpredictable and recurrent seizures. The majority of patients with temporal lobe epilepsy (TLE), which is the most common type of epilepsy, have to live not only with seizures but also with behavioral alterations, including anxiety, psychosis, depression, and impaired cognitive functioning. The pilocarpine model has been recognized as an animal model of TLE. However, there are few studies addressing behavioral alterations in the maturation phase when evaluating the time course of the epileptogenic process after pilocarpine administration. Therefore, the present work was designed to analyze the neurobehavioral impairments of male adult Wistar rats during maturation and chronic phases in the pilocarpine model of epilepsy. Behavioral tests included: open-field tasks, olfactory discrimination, social recognition, elevated plus maze, and the forced swimming test. The main behavioral alterations observed in both maturation and chronic phases of the pilocarpine model were olfactory and short-term social memory deficits and decrease in the immobility time in the forced swimming test. Moreover, increased anxiety-like responses were only observed in the maturation phase. These findi...Continue Reading

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Citations

Apr 27, 2016·Epilepsy & Behavior : E&B·Christian Brandt, Marco Mula
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Oct 13, 2019·The European Journal of Neuroscience·Laëtitia Chauvière
Jan 26, 2021·Cellular and Molecular Neurobiology·M CrespoM Martín

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