PMID: 1197574Oct 14, 1975Paper

Time course for the effects of cocaine on fixed-ratio water-reinforced responding in rats

Psychopharmacologia
R C Macphail, L S Seiden

Abstract

Four male rats performed during 35-min sessions under a schedule that arranged water delivery (0.04 ml) after every fortieth response. Cocaine (1.0-16.0 mg per rat, i.p.) was administered 15 min, 30 min, 60 min or 120 min prior to a session. When given 15 min prior to a session, cocaine (1.0-8.0 mg) in all rats produced dose-related decreases in responding. The largest dose, when given 15 min pre-session to two rats, almost completely suppressed responding. Lengthening the time between drug injection and test session attenuated the rate-decreasing effects of cocaine (1.0-8.0 mg), but did not affect the almost complete suppression of performance seen with the largest dose. Small doses (1.0-4.0 mg) had no effect on the pause in responding that occurred after water delivery. The 8.0-mg dose lengthened the pause by approximately 9000% and 650% when given 15 and 30 min prior to a session, respectively, but by less than 50% when given 60 or 120 min pre-session. Cocaine effects depend on the dose as well as the time of its administration prior to testing.

References

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Citations

Jul 1, 1979·European Journal of Pharmacology·L D Byrd
Jun 1, 1977·Pharmacology, Biochemistry, and Behavior·D A Downs, M C Braude
Sep 1, 1978·Pharmacology, Biochemistry, and Behavior·W L WoolvertonC R Schuster
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·J A BedfordM C Wilson
May 1, 1982·Pharmacology, Biochemistry, and Behavior·M N Branch, M E Dearing
Aug 1, 1989·Pharmacology, Biochemistry, and Behavior·D M GrillyT W Grogan
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·M N Branch, G M Sizemore
Sep 1, 1988·Electroencephalography and Clinical Neurophysiology·R Gritzke, M W Church
Jan 15, 2008·Pharmacology, Biochemistry, and Behavior·Julie A Marusich, Marc N Branch
Sep 11, 2013·Journal of the Experimental Analysis of Behavior·Vanessa Minervini, Marc N Branch
Sep 1, 1991·Journal of the Experimental Analysis of Behavior·C E Hughes, M N Branch
Apr 9, 2002·Journal of the Experimental Analysis of Behavior·Linda Ross, David W Schaal
Mar 1, 1978·Journal of the Experimental Analysis of Behavior·M S Moore, D M Thompson
May 1, 1987·Journal of the Experimental Analysis of Behavior·S H HoffmanG M Sizemore
Jan 1, 1980·Journal of the Experimental Analysis of Behavior·L D Byrd

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