PMID: 9543433Apr 16, 1998Paper

Time-course imaging of rat embryos in utero with magnetic resonance microscopy

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
B R SmithG A Johnson

Abstract

Magnetic resonance (MR) microscopy was used to noninvasively investigate the development of live rat embryos in utero. The difficulty in making sequential observations of a developing mammalian embryo has frustrated developmental biologists for many years. Most current technologies analyze normal and abnormal development by observing end point phenotypes (in fixed specimens) rather than investigating the live embryo. MR microscopy was adapted to allow rat litters to be scanned three times each (at 1- to 3-day intervals) and has produced images of live developing embryos. It was demonstrated that repeated anesthesia and imaging protocols produced no gross malformations in the rat pups that were subsequently delivered and observed. Three-dimensional projection encoding with phase rewinders produced isotropic [256(3)] image data sets in about 30 minutes with excellent tissue contrast arising from steady-state effects in the amniotic fluid.

References

Dec 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H Glover, J M Pauly
Mar 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·B R SmithG A Johnson
Oct 1, 1986·Investigative Radiology·S N BoneM B Thompson
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·B R SmithE Linney
Jan 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S L GewaltG A Johnson
Feb 15, 1996·The Journal of Clinical Investigation·K R Chien
Mar 15, 1996·The Journal of Clinical Investigation·A Nagy, J Rossant
Nov 1, 1996·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·B R SmithG A Johnson
Nov 14, 1997·IEEE Transactions on Bio-medical Engineering·H H QiuG A Johnson
Nov 1, 1996·Trends in Cardiovascular Medicine·B R Smith

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Citations

Nov 14, 2000·The Anatomical Record·B HogersR E Poelmann
Nov 6, 2003·Magnetic Resonance Imaging·Nilesh R GhugreJohn C Wood
Mar 26, 1999·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·R E JacobsD Laidlaw
Jan 29, 1999·Environmental Health Perspectives·J F Medlin
Feb 27, 2001·AJR. American Journal of Roentgenology·R W Sze, K E Yutzey
Jan 30, 2008·Journal of Pharmaceutical Sciences·I RodríguezJ Ruíz-Cabello
Jun 4, 2004·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·J Puerta-FonolláA Peña-Melián
Nov 13, 2008·NMR in Biomedicine·Bianca HogersRobert E Poelmann
Jun 13, 2001·Developmental Biology·M DhenainR E Jacobs
Feb 17, 2001·Microscopy Research and Technique·B R Smith
May 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Abby E DeansDaniel H Turnbull
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A K HoyduJ S Leigh
Nov 17, 2005·Journal of the American Chemical Society·Quan ZhengWen-Hong Li

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