PMID: 9542757Jun 6, 1998Paper

Time course of 8-methoxypsoralen-induced skin photosensitization in PUVA-bath photochemotherapy

Photodermatology, Photoimmunology & Photomedicine
T ReutherM Kerscher

Abstract

In recent years PUVA-bath photochemotherapy has been shown to be an effective treatment modality for several dermatoses. A limitation of PUVA-bath photochemotherapy has been the lack of guidelines for optimal performance, including the time course of photosensitization of the skin exposed to the 8-methoxypsoralen (8-MOP) bath water solution. In the present study 12 healthy volunteers were exposed to a 20 min bath in 150 l of an 8-MOP water solution (0.5 mg/l, 37 degrees C). Immediately, as well as 1, 2, 3 and 5 h after the 8-MOP bath, irradiation was performed with increasing doses of UVA (0.5, 1, 2, 3, 5 J/cm2) on 2 cm2 test areas. The minimal phototoxic dose (MPD) was determined 72 h after the UVA exposure. In all volunteers, photosensitization was highest immediately after the bath, with a MPD significantly below 5 J/cm2 (0.5-2 J/cm2). One hour after the bath, erythema could be induced by 2 to 5 J/cm2 UVA. Two hours after the bath, erythema could be induced using irradiation of 5 J/cm2 only in two volunteers. Three and five hours after the 8-MOP bath, no erythema could be induced in any volunteer by UVA doses up to 5 J/cm2. Our results indicate that optimal bath-PUVA requires UVA irradiation immediately after the 8-MOP bath....Continue Reading

References

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Citations

Jan 29, 2000·The British Journal of Dermatology·S M HalpernL E Rhodes
Aug 21, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H Stege
Dec 30, 1999·Pigment Cell Research·M C IsoldiA M Castrucci
Jul 10, 2001·Journal of Cutaneous Medicine and Surgery·Y AraganeT Tezuka

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