Time course of blast-induced injury in the rat auditory cortex

PloS One
S KallakuriJinsheng Zhang

Abstract

Blast exposure is an increasingly significant health hazard and can have a range of debilitating effects, including auditory dysfunction and traumatic brain injury. To assist in the development of effective treatments, a greater understanding of the mechanisms of blast-induced auditory damage and dysfunction, especially in the central nervous system, is critical. To elucidate this area, we subjected rats to a unilateral blast exposure at 22 psi, measured their auditory brainstem responses (ABRs), and histologically processed their brains at 1 day, 1 month, and 3-month survival time points. The left and right auditory cortices was assessed for astrocytic reactivity and axonal degenerative changes using glial fibrillary acidic protein immunoreactivity and a silver impregnation technique, respectively. Although only unilateral hearing loss was induced, astrocytosis was bilaterally elevated at 1 month post-blast exposure compared to shams, and showed a positive trend of elevation at 3 months post-blast. Axonal degeneration, on the other hand, appeared to be more robust at 1 day and 3 months post-blast. Interestingly, while ABR threshold shifts recovered by the 1 and 3-month time-points, a positive correlation was observed between r...Continue Reading

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Citations

Dec 5, 2019·The Journal of the Acoustical Society of America·Jinsheng Zhang
Jun 9, 2020·Frontiers in Neurology·Peethambaran ArunJoseph B Long
Aug 7, 2021·Frontiers in Cell and Developmental Biology·Jiaoying JiaMengqiang Yu

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