Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Critical Care : the Official Journal of the Critical Care Forum
Thiago Domingos CorrêaStephan Mathias Jakob

Abstract

A decrease in blood lactate levels (Lac) >10% during the first hours of resuscitation in sepsis is associated with better outcomes, but the mechanisms are unclear. Our objective was to investigate the relationship between the time course of Lac, inflammatory response, and mitochondrial respiration during experimental sepsis. Original data from two previously published studies were reanalyzed. In cohort 1, pigs were randomized to be resuscitated for 48 h starting at 6, 12, and 24 h, respectively, after fecal peritonitis induction (n = 8 each). Animals were categorized according to the decrease in Lac during the first 6 h of resuscitation (early if ≥10% [Lac ≥10%] or late if <10% or increased [Lac <10%]), and systemic hemodynamics, inflammatory parameters, and mitochondrial function were compared between groups. In a second group of animals with fecal peritonitis and 24 h of resuscitation (n = 16, cohort 2), abdominal regional Lac exchange was measured, and animals were categorized according to the decrease in Lac as in cohort 1. Overall mortality was 20% (4 of 20) in the Lac ≥10% group and 60% (12 of 20) in the Lac <10% group (p = 0.022). In cohort 1, systemic hemodynamics were similar in the Lac ≥10% (n = 13) and Lac <10% (n = ...Continue Reading

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Citations

Feb 12, 2020·Critical Care : the Official Journal of the Critical Care Forum·Jonathan GripOlav Rooyackers
Sep 10, 2020·Frontiers in Medicine·Tamara MerzOscar McCook
Sep 19, 2020·Critical Care Medicine·Sivasubramanium V BhavaniBhakti K Patel
Oct 30, 2020·Intensive Care Medicine Experimental·Thiago Domingos CorrêaStephan Mathias Jakob
Nov 2, 2020·Internal and Emergency Medicine·Francesca InnocentiRiccardo Pini
Apr 27, 2021·American Journal of Physiology. Renal Physiology·Jianni HuangShougang Zhuang

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Methods Mentioned

BETA
biopsies

Software Mentioned

Prism
SPSS Statistics

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