PMID: 6166876Jun 1, 1981Paper

Time course of capsaicin-induced functional impairments in comparison with changes in neuronal substance P content

Naunyn-Schmiedeberg's Archives of Pharmacology
F Lembeck, J Donnerer

Abstract

1. Changes in the content of substance P (dorsal spinal cord, dorsal roots, dorsal root ganglia, saphenous nerve, skin) and functional changes (neurogenic plasma extravasation, chemosensitivity of the cornea) were measured in the rat from 10 min to 4 days after the s.c. injection of a single dose of 50 mg kg-1 capsaicin. 2. The substance P content in dorsal roots, saphenous nerve and hind paw skin progressively declined to about 60--70% of control 4 days after treatment, whereas that of the dorsal root ganglia rose, after an initial decline, to 140% after 1--4 days. 3. After denervation, impairment of neurogenic plasma extravasation could be observed not earlier than after one day, thus being comparable in time course to the depletion of substance P in the skin and saphenous nerve. 4. Neurogenic plasma extravasation and the chemosensitivity of the cornea were greatly diminished already 10 min after systemic capsaicin treatment, i.e. at a time when the substance P content of the peripheral nerve was still unchanged. These early effects of systemic capsaicin treatment are therefore caused by actions other than depletion of substance P.

References

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Citations

Jul 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J Donnerer, F Lembeck
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·A HaraK Kisara
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·R Gamse
Mar 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·G SkofitschF Lembeck
Oct 28, 1982·Brain Research·M S MillerT F Burks
Jun 1, 1984·European Journal of Pharmacology·G BynkeF Sundler
Aug 3, 1984·European Journal of Pharmacology·C A MaggiA Meli
Sep 21, 1990·European Journal of Pharmacology·R AmannF Lembeck
May 31, 1982·Life Sciences·S H BuckT F Burks
Oct 8, 1984·Life Sciences·A G HayesR G Hill
Jan 1, 1984·Pharmacology & Therapeutics·T Hori
Jan 1, 1988·Pharmacology & Therapeutics·L A Chahl
Dec 1, 1984·Brain Research·L C Russell, K J Burchiel
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Nov 1, 1994·General Pharmacology·D T ScottW R Ferrell
Feb 1, 1996·Journal of Chemical Neuroanatomy·P I MappH Cambridge
Feb 1, 1985·Journal of the Autonomic Nervous System·P J GallagherS W White
Nov 13, 2008·Regulatory Peptides·Nuray ErinSerife Tütüncü
Jun 23, 2009·European Journal of Pain : EJP·Christina BrockAsbjørn Mohr Drewes

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