Time course of cardiovascular neural regulation during programmed 20-sec apnea in rats

Critical Care Medicine
Tzong-Bor SunTerry B J Kuo

Abstract

Long-term hypoxia results in hemodynamic breakdown in patients in the intensive care unit; however, intermittent hypoxia causes hypertension in individuals with sleep apnea. The objective of this study was to explore the sequential cardiovascular neural alterations in response to acute hypoxic apnea. The authors conducted a prospective, randomized animal study. The study was conducted in a university animal laboratory. A programmable apnea model was developed in anesthetized rats, in which a 20-sec period of apnea was produced and subsequently divided into the early (2.0 to 7.9 secs), middle (8.0 to 13.9 secs), and late apneic phases (14.0 to 19.9 secs) and immediate reventilatory phase (20.0 to 25.9 secs). Evident hypoxia developed during 20-sec apnea. Arterial pressure increased in the early apneic phase and returned to control level in the middle phase. Significant hypotension developed in the late apneic phase and deteriorated in the reventilatory phase. Interbeat interval increased mildly along the apneic event. The increase of pressure in the early and middle phases was inhibited by propranolol (1.0 mg/kg intravenously [iv]) but was provoked by phentolamine (2.5 mg/kg iv). The decrease of pressure in the late and reventil...Continue Reading

References

Aug 1, 1991·Circulation·A MallianiS Cerutti
Jun 1, 1990·Journal of the Autonomic Nervous System·N JapundzicJ L Elghozi
Jun 1, 1990·The American Journal of Physiology·C H Orchard, J C Kentish
Jan 1, 1985·Journal of Applied Physiology·J H Ashton, S S Cassidy
Feb 1, 1997·The American Journal of Physiology·S J HarkemaR A Meyer
Feb 14, 1998·Journal of Applied Physiology·S KatragaddaB J Morgan
Mar 10, 2000·Journal of Applied Physiology·H SchneiderC P O'Donnell
Apr 28, 2000·Pflügers Archiv : European journal of physiology·C C Yang, T B Kuo
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P Van De BorneV K Somers
Mar 7, 2001·Hypertension·N L KanagyL D Nelin
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R M MohanD J Paterson
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·N R PrabhakarE C Fletcher
Sep 25, 2001·Journal of Applied Physiology·A XieB J Morgan
Dec 4, 2001·Advances in Experimental Medicine and Biology·Y PengN R Prabhakar
Jun 24, 2003·Journal of Applied Physiology·Anna BlasiMichael C K Khoo
Nov 19, 2003·The European Journal of Neuroscience·David GozalShang Z Guo

❮ Previous
Next ❯

Citations

Jul 23, 2008·Bulletin of Experimental Biology and Medicine·E V Sal'nikovM V Grigor'eva
Jul 19, 2011·Experimental Physiology·Guus H M SchoorlemmerSérgio L Cravo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.