PMID: 9421455Jan 8, 1998Paper

Time course of cerebral edema after traumatic brain injury in rats: effects of riluzole and mannitol

Journal of Neurotrauma
F M BareyreJ M Stutzmann

Abstract

Brain trauma is the main cause of morbidity and mortality in young adults. One delayed events that occurs after a head trauma and compromises the survival of patients is cerebral edema. The present study examined first the occurrence of cerebral edema after a traumatic brain injury (TBI) induced by moderate fluid percussion in rats. Brain water content was measured from 1 h to 7 days posttrauma, in the hippocampus and cortex, on both ipsi- and contralateral hemispheres. Second, the effects of mannitol, an osmotic agent frequently used in the clinic, and riluzole, a neuroprotective compound, were investigated on regional edema formation. After TBI, the ipsilateral edema began early at 1-6 h, was maximal at 48 h and was resorbed by 5-7 days. No edema was observed in the contralateral hemisphere. Mannitol at 1 g/kg or vehicle was administered iv 15 min, 2 h and 4 h postinjury. At this dose, mannitol significantly attenuated the ipsilateral injured cortex edema measured at 6 h (p < 0.05). Riluzole at 4 and 8 mg/kg or vehicle was administered 15 min (IV) and 6 h, 24 h, and 30 h (SC) post-TBI. Riluzole at 4 x 4 mg/kg significantly reduced edema measured at 48 h, in the ipsilateral hippocampus (p < 0.05), whereas at 4 x 8 mg/kg, the r...Continue Reading

References

Oct 1, 1992·Journal of Neurosurgery·A M Kaufmann, E R Cardoso
Dec 1, 1991·Pflügers Archiv : European journal of physiology·E Benoit, D Escande
Jan 1, 1990·Journal of Neurotrauma·Y ShapiraE Shohami
Sep 1, 1989·Neurological Research·Y ShapiraE Shohami
Oct 1, 1988·Critical Care Medicine·B K Siesjö
Jun 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ShapiraE Shohami
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S HatashitaS M Salamat
Jan 1, 1987·Central Nervous System Trauma : Journal of the American Paralysis Association·T K McIntoshA I Faden
Jan 1, 1967·Journal of Neuropathology and Experimental Neurology·I Klatzo
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö
Aug 1, 1994·Journal of Neurotrauma·T A Gennarelli
Mar 3, 1994·The New England Journal of Medicine·G BensimonV Meininger
Jan 12, 1993·European Journal of Pharmacology·F WahlR G Boulu
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonA J Hansen
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonA J Hansen
Jan 1, 1996·The American Journal of Emergency Medicine·M H Biros, R Nordness
Jan 31, 1996·Neuroreport·J M StutzmannC Gross
Sep 1, 1996·Journal of Neurosurgery·S A BaldwinS W Scheff
Jun 27, 1996·European Journal of Pharmacology·M A PettyJ Wagner
Oct 1, 1995·Brain Pathology·D I GrahamT A Gennarelli

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Citations

Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·P M Lea, A I Faden
Oct 28, 2003·Journal of Neurotrauma·Douglas S DeWitt, Donald S Prough
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Nov 26, 2009·Journal of Neurotrauma·Christine CharrueauChristophe Moinard
Aug 27, 2009·Journal of Neurotrauma·Thomas LescotCatherine Marchand-Leroux
Nov 11, 2009·The Journal of Trauma·Geoffrey T Desmoulin, Jean-Philippe Dionne
Aug 14, 2008·CNS Drugs·Christopher PittengerGerard Sanacora
Sep 17, 2013·Journal of Neurosurgery·Abdulghader M AlfasiMarc R Del Bigio
Sep 1, 2012·Translational Stroke Research·Robert A HetzCharles S Cox
Oct 3, 2006·Current Opinion in Anaesthesiology·D K Menon, A C Summors
Mar 3, 2009·Expert Opinion on Emerging Drugs·Ye XiongMichael Chopp
May 14, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·James J DonkinRobert Vink
Nov 25, 2004·Neuroscience·A W UnterbergK L Kiening
May 9, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Linda BelabedChristophe Moinard
May 6, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·T LescotL Puybasset
Jun 27, 2015·Journal of Neurosurgery·Stephen M WilsonEdward F Chang
Mar 1, 2012·Respiratory Physiology & Neurobiology·Hung-Fu LeeYu Ru Kou
Jul 4, 2015·Neuron·Sachin P GadaniJonathan Kipnis
Sep 24, 2008·Handbook of Clinical Neurology·Claire Henchcliffe, M Flint Beal
Nov 21, 2015·Stem Cells Translational Medicine·Daniel J KotaScott D Olson
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ChatzipanteliW D Dietrich
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J A CheneyT K McIntosh

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Brain Injury & Trauma

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