Time course of changes in contrast sensitivity following intravitreal ranibizumab injection for branch retinal vein occlusion.

Japanese Journal of Ophthalmology
Yoshimi SugiuraTetsuro Oshika

Abstract

To evaluate contrast sensitivity (CS) in patients with branch retinal vein occlusion (BRVO) following intravitreal ranibizumab injection (IVR), and to investigate the relationship between CS and retinal microstructure. A retrospective, observational case series. We included 23 eyes with treatment naïve BRVO followed up for 6 months after treatment. Best-corrected visual acuity (BCVA), letter contrast sensitivity (LC), and 10% low contrast visual acuity (LCVA) were measured. All tests were performed before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on optical coherence tomography (OCT) images, we assessed central retinal thickness (CRT), presence of serous retinal detachment (SRD), and status of the external limiting membrane (ELM) and ellipsoid zone (EZ). IVR treatment significantly improved CS (LC: P < 0.0001, LCVA: P = 0.004) as well as BCVA (P = 0.015) and CRT (P < 0.0001). LC and LCVA at 6 months after treatment were significantly correlated with presence of SRD before treatment. At 6 months after treatment, LCVA was significantly correlated with pre-treatment CRT (P = 0.042). In patients with good baseline BCVA, LCVA showed significant improvements (P = 0.022) although their BCVA did not change. In patients wit...Continue Reading

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Jul 9, 2013·American Journal of Ophthalmology·Fumiki OkamotoTetsuro Oshika
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Citations

Jul 13, 2021·Japanese Journal of Ophthalmology·Shohei MorikawaTetsuro Oshika
Aug 29, 2021·The British Journal of Ophthalmology·Tomoya MurakamiTetsuro Oshika

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