Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats

Brain Research
Z G NiAbdelhamid Benazzouz

Abstract

The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53+/-0.56 and 7.66+/-0.73 spikes/s, respectively) compared to normal rats (11.13+/-0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71+/-0.51 spikes/s during the 3rd week and 11.13+/-0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at wee...Continue Reading

Citations

Jan 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abdelhamid BenazzouzChristian Gross
May 27, 2014·Frontiers in Aging Neuroscience·Abdelhamid BenazzouzJonathan Chetrit
Jul 31, 2003·Journal of Neurochemistry·Gustavo Pacheco-LópezManfred Schedlowski
Mar 26, 2010·Synapse·Teresa Morera-HerrerasLuisa Ugedo
Oct 5, 2012·Annals of Neurology·Chun-Hwei TaiChung-Chin Kuo
Jan 14, 2017·American Journal of Alzheimer's Disease and Other Dementias·Shuang WangJian Cao
Oct 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chun-Hwei TaiAbdelhamid Benazzouz
Nov 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J BaufretonA I Taupignon
Sep 10, 2014·The Journal of Clinical Investigation·Ming-Kai PanChung-Chin Kuo
May 5, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Michael S RemplePeter E Konrad
Feb 18, 2014·Pflügers Archiv : European journal of physiology·Ya-Chin YangChung-Chin Kuo
Aug 28, 2020·The European Journal of Neuroscience·Alessandro StefaniSalvatore Galati

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