Time course of chronic diazepam effects on the auditory evoked potential of the rat

European Journal of Pharmacology
M L JongsmaA M Coenen

Abstract

The time course of chronic diazepam effects on auditory evoked potentials was studied in rats. Auditory evoked potentials were elicited by background and target tones in a passive oddball paradigm. Diazepam was administered by slow release implants to establish constant blood concentrations. Recordings were made during 21 days of treatment and 9 days after treatment ceased. Diazepam increased the amplitude of the P40 component and decreased the amplitude of the P72-P102 components elicited by background tones. Diazepam increased the amplitude of the P40-P48 component and decreased that of the N58 component elicited by target tones. These effects remained constant during treatment. Diazepam further decreased the amplitude of the P102 component elicited by target tones. This effect became more distinct over time. No group differences were found 9 days after treatment. The constant drug effects on middle-latency components (P40-P48) might reflect diazepam-induced changes in sensory information processing. The decreased long-latency component (P102) might reflect a diminished attention to, or discrimination of, target tones. The time course of this effect might reflect diazepam-enhanced habituation.

References

Jul 1, 1992·Electroencephalography and Clinical Neurophysiology·J G Van DijkA H Zwinderman
Jul 1, 1992·Biological Psychology·F MartinR Dick
Jan 1, 1992·Journal of Neural Transmission. General Section·C L Ehlers, R I Chaplin
Jan 1, 1991·Psychopharmacology·H V Curran
Jan 1, 1991·Electroencephalography and Clinical Neurophysiology·M E BrandtJ P Carbonari
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·C L EhlersR I Chaplin
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·S E File
Mar 1, 1986·Electroencephalography and Clinical Neurophysiology·J Polich
May 1, 1989·Pharmacology, Biochemistry, and Behavior·S M AntelmanS Knopf
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S E File, S J Cooper
May 1, 1988·Psychological Medicine·S GolombokM Lader
Jan 1, 1986·Psychopharmacology·H FriedmanR I Shader
Jan 1, 1988·Progress in Neurobiology·N A Shaw
Jan 1, 1987·Physiology & Behavior·B J HurlbutS M Satterfield
Nov 1, 1985·Experimental Neurology·W Löscher, W S Schwark
Apr 1, 1993·Electroencephalography and Clinical Neurophysiology·S Makeig
Oct 1, 1996·British Journal of Clinical Pharmacology·J WanH H Zhou

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Citations

Oct 9, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo Maria Rossini
Jul 31, 2007·European Journal of Pharmacology·Anke SambethArjan Blokland
Aug 10, 2001·Journal of Neurophysiology·A Disney, M B Calford

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