Time course of development of supersensitivity to topical acetylcholine in partially isolated cortex

Electroencephalography and Clinical Neurophysiology
F A ECHLIN

Abstract

In alert monkeys the time course for development of supersensitivity to topical acetylcholine in partially isolated frontal cerebral cortex was determined. Thresholds for paroxysmal discharge fell progressively and markedly during 3 weeks, further in 5 and somewhat more after 6 months. ACh supersensitivity was demonstrated in chronic "isolated" occipital cortex. Epileptiform discharges were recorded selectively from chronic partially isolated frontal cortex on peripheral nerve stimulation and these spread, causing a clinical convulsive siezure when the open end of the isolation extended into the precentral gyrus. The basic mechanisms responsible for the supersensitivity are unknown but evidence presented and much in the pertinent literature is in keeping with the hypothesis that partial isolation of cortical cells, i.e., denervation, deafferentation, or disuse may be important. It is suggrested that peripheral nerve stimulation, like arousal, may cause an outflow of ACh on the normal brain surface and over the open end of a partially isolated area, which, especially, in the presence of a diminished cholinesterase activity (in partially isolated cortex), could act like topical ACh, cause a DC shift and an epileptiform discharge.

References

Apr 1, 1992·Electroencephalography and Clinical Neurophysiology·S J Pierre-Louis, F MORRELL
Jun 20, 1998·Journal of Cognitive Neuroscience·J M HopfM Meng

Citations

May 1, 1971·Electroencephalography and Clinical Neurophysiology·J H Ferguson, H H Jasper
Aug 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Reiffenstein, C Triggle
Feb 1, 1974·Electroencephalography and Clinical Neurophysiology·J H Ferguson, D R Cornblath
Sep 1, 1967·Electroencephalography and Clinical Neurophysiology·L T RutledgeJ A Duncan
Sep 1, 1970·Electroencephalography and Clinical Neurophysiology·K KrnjevićA Silver
Jul 1, 1968·The Journal of Nervous and Mental Disease·P Rosenberg, F A ECHLIN
Dec 1, 1967·Archives of Neurology·J D Loeser, A A Ward
Jan 1, 1952·Transactions of the American Neurological Association·F A ECHLIND PECK
Nov 1, 1957·Electroencephalography and Clinical Neurophysiology·B GRAFSTEIN, P B SASTRY
Nov 1, 1959·Electroencephalography and Clinical Neurophysiology·F A ECHLIN
Apr 1, 1962·Electroencephalography and Clinical Neurophysiology·S K SHARPLESS, L M HALPERN
Aug 1, 1963·Archives of Neurology·F A ECHLIN, A BATTISTA
Aug 1, 1959·Archives of Neurology·F MORRELL
Feb 1, 1952·Electroencephalography and Clinical Neurophysiology·C E HENRY, W B SCOVILLE
Apr 15, 1950·The Journal of Physiology·B D Burns
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Related Concepts

Adrenal Cortex Diseases
Occipital Lobe
Administration, Topical
Non-epileptic Convulsion
Structure of Broca's Area
Denervation
Acetylcholine Sulfate (1: 1)
Macaca
Metazoa
Electric Stimulation Technique

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