PMID: 574284Sep 1, 1979

Time course of dopaminergic hypersensitivity following chronic narcotic treatment

Pharmacology, Biochemistry, and Behavior
K R Carlson, J Almasi


Guinea pigs were injected SC for 3 weeks with 3 different dosage schedules of morphine or methadone, or with saline. For 8 weeks thereafter they were challenged weekly with the dopamine agonist apomorphine. Hypersensitivity was manifested in more intense stereotypies, as compared to the saline group, by all morphine and methadone groups. Hypersensitivity persisted longer after the termination of methadone treatment (maximum of 8 weeks) than after morphine administration (maximum of 3 weeks). The degree of hypersensitivity, and its duration after treatment, was positively related to methadone dosage. In some groups a period of hyposensitivity was seen following hypersensitivity. These data are interpreted with reference to the hypothesized mechanism underlying the development of hypersensitivity, the different durations of action of morphine and methadone, and the retention of methadone in brain following treatment.


May 31, 1978·Psychopharmacology·K R Carlson, J Almasi
Jan 1, 1977·Progress in Neuro-psychopharmacology·P Moleman, J Bruinvels
Aug 1, 1976·Pharmacology, Biochemistry, and Behavior·R D Eibergen, K R Carlson
Nov 24, 1976·Psychopharmacology·L M Gunne, S Bárány
Jan 1, 1976·Annals of the New York Academy of Sciences·K R Carlson, R D Eibergen
Aug 1, 1972·Journal of Neurochemistry·H A SasameG L Gessa
Jan 1, 1972·Journal of Neural Transmission·H L Klawans, R Rubovits
Aug 15, 1972·Experientia·J Perez-CruetG L Gessa
Jan 1, 1971·Psychopharmacologia·H LalS K Puri


May 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·A ZharkovskyL Ahtee
May 1, 1981·Pharmacology, Biochemistry, and Behavior·A E LangleyT Lehman
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·K R Carlson, T F Seeger
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·K R Carlson, D O Cooper
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·J Pollock, Conan Kornetsky
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·T P PiepponenL Ahtee
Oct 1, 1988·Psychiatry Research·J P LindenmayerS Zukin
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·Conan Kornetsky

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