Time-course of effects of toluene on microsomal enzymes in rat liver, kidney and lung during and after inhalation exposure

Chemico-biological Interactions
K Pyykkö

Abstract

Inhalation of toluene vapour of 2000 ppm increased the activities of aniline hydroxylase, aminopyrine N-demethylase, aryl hydrocarbon hydroxylase and NADPH-cytochrome c reductase and the concentrations of cytochromes P-450 and b5 in liver microsomes of adult male rats after an exposure period of 1 day or less. Repeated treatments, 8 h daily for 1-16 days, had only a slight further effect. In lung microsomes, the activities of monooxygenases and the concentration of cytochrome P-450 decreased after 6-24 h toluene exposure, but those of cytochrome b5 and NADPH-cytochrome c reductase did not change. In kidney microsomes the changes were mostly insignificant. After discontinuation of exposure the activities of enzymes and the concentrations of cytochromes returned to the control level in 1-4 days. The results obtained resemble the time-courses for the induction of monooxygenases by other inducers. The tissue differences suggest the unequal distribution of various cytochrome P-450 forms and their individual responsiveness to induction in liver, kidneys and lungs.

References

Apr 1, 1978·Toxicology and Applied Pharmacology·A Aitio, M G Parkki
Aug 11, 1975·American Industrial Hygiene Association Journal·C S McCammonR E Kupel
Nov 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Vainio
Mar 1, 1974·Bulletin of Environmental Contamination and Toxicology·C L Litterst, E J van Loon
Oct 1, 1973·Toxicology and Applied Pharmacology·F U SaitoR Snyder
Nov 17, 1980·Biochimica Et Biophysica Acta·K Pyykkö
Feb 1, 1981·Mechanisms of Ageing and Development·D L Schmucker, R K Wang
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·D W NebertA B Okey

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Citations

Dec 1, 1994·The International Journal of Biochemistry·T Nakajima, R S Wang
Sep 1, 1984·Mutation Research·B L HarperM S Legator
Nov 1, 1987·Toxicology Letters·S Chakrabarti, B Tuchweber
Jul 25, 2000·Journal of Clinical Pharmacy and Therapeutics·E TanakaS Misawa
Jan 1, 1988·Journal of Toxicology and Environmental Health·A E RobertsR A Schatz
Dec 1, 1994·Journal of Toxicology and Environmental Health·S H ParkR A Schatz
Feb 1, 1985·British Journal of Industrial Medicine·M WallénM B Nordqvist
Jan 1, 1990·British Journal of Industrial Medicine·A Moretto, M Lotti
Dec 1, 1993·Environmental Health Perspectives·E Reese, R D Kimbrough
May 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J A StickneyR A Schatz
Jun 1, 1989·Environmental Research·G C HsiehR D Parker
Mar 17, 2007·Inhalation Toxicology·Bengu CobanogluOrhan Yalcin
Dec 23, 1998·Critical Reviews in Toxicology·A Löf, G Johanson
Sep 1, 1984·Acta Oto-laryngologica·I PyykköM Juhola

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