Time-course of health status in patients with rheumatoid arthritis during the first year of treatment with infliximab

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Akihiko BanYoshiki Nishizawa

Abstract

A longitudinal study was performed to examine changes in health status in comparison with rheumatoid arthritis (RA) inflammation in patients with RA during the first 54 weeks of infliximab (IFX) treatment. Health status in active RA patients (n=13) was assessed monthly using the Arthritis Impact Measurement Scale 2 (AIMS2) and the VAS-GH during the first year of IFX treatment. Simultaneously, RA activity was assessed using inflammation markers, MMP-3 and the Disease Activity Score in 28 joints (DAS-28) based on CRP [DAS-28(CRP)] and ESR[DAS-28(ESR)]. Serum CRP and ESR decreased significantly from 2.14+/-0.52mg/dL and 56.9+/-6.96mm/h, respectively, at baseline to 0.24+/-0.11mg/dL and 31.6+/-4.39mm/h, respectively, at 2 weeks after initiation of IFX. Other inflammatory markers and MMP-3 were also suppressed significantly after 2 weeks of IFX treatment. DAS-28(CRP) and DAS-28(ESR) were also significantly decreased after 2 weeks and suppression of both DAS values remained significant until 54 weeks of IFX treatment. After initiation of IFX, patient-reported general health also showed a significant improvement based on the changes in the six summary component scores on the AIMS2 (physical, affect, symptom, role, social interaction, ...Continue Reading

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Citations

Apr 2, 2014·TheScientificWorldJournal·Bhupinder KapoorYogyata Vaidya
Jan 21, 2016·International Journal of Rheumatology·Oddgeir SelaasKarl A Brokstad
May 28, 2019·Journal of Clinical Medicine·Mélanie Rinaudo-GaujousHubert Marotte
Jan 23, 2021·Critical Reviews in Oncology/hematology·Rebekah PattonBarry J A Laird
Mar 31, 2011·Current Opinion in Rheumatology

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