PMID: 8968409Dec 6, 1996Paper

Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids

Journal of Toxicology and Environmental Health
M H SiessM Suschetet

Abstract

Effects of continuous feeding flavonoids (flavone, flavanone, and tangeretin) on drug-metabolizing enzymes in rat liver were investigated to ascertain how long feeding is required to reach maximal induction and to determine whether maximal induction is maintained for a long period of feeding. In the first experiment rats received a diet containing 10 mmol flavonoid/kg dry matter for 4, 8, 16, or 32 d. The second experiment was designed to examine the time course for induction during the first 4 d. The kinetics of induction depended on the chemical structure of the flavonoid and was different from one enzyme to another. Flavone increased P450 1A and P450 2B apoproteins and stimulated many enzyme activities. A significant increase of P450 1A1/2 proteins, ethoxyresorufin O-deethylase (EROD), and methoxyresorufin O-demethylase (MROD) activities occurred as early as 6 h after the first administration, and a gradual increase was observed up to 4 d of feeding. P450 2B1/2 proteins and pentoxyresorufin O-depentylase (PROD) activity were also increased but after a lag period when compared with P450 1A1/2 proteins. EROD and MROD activities declined after 4 d, whereas PROD activity remained steady during 32 d of flavone feeding. Glutathion...Continue Reading

Citations

May 16, 2007·Archives of Toxicology·Alyson E MitchellJaime L Rudolf
Nov 28, 2002·Pharmacology & Therapeutics·Bent H Havsteen
Aug 10, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S E NielsenL O Dragsted
Jun 1, 2000·Nutrition Research Reviews·G G DuthieJ A Kyle
Nov 16, 2007·Nutrition and Cancer·Misty R Saracino, Johanna W Lampe
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Lara GibelliniAndrea Cossarizza
Jul 16, 2010·World Journal of Gastroenterology : WJG·Xiao-Hong YangYuan Lv
Aug 8, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jingling TangZhonggui He
Nov 18, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Young Jin MoonMarilyn E Morris

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