Time-course of lipid peroxidation in different organs of mice treated with Echis pyramidum snake venom

Journal of Biochemical and Molecular Toxicology
Abdurrahman Al AsmariHaseeb Ahmad Khan

Abstract

This study examined the effect of Echis pyramidum (EP) venom on time-course of lipid peroxidation in different vital organs of mice. Adult male Swiss albino mice were injected with EP venom (2 mg/kg, i.p.); control mice received vehicle alone (normal saline). Mice were killed at 1, 3, 6, 12, and 24 h post-envenomation. The liver, lung, kidney, heart, and brain (cerebrum and cerebellum) were collected for the estimation of malondialdehyde (MDA), an index of lipid peroxidation. The results of this study showed that a single injection of EP venom caused a significant lipid peroxidation in all the organs studied. The onset of lipid peroxidation was as early as 1 h and persisted for several hours, suggesting an important role of oxidative stress in the cytotoxicity of EP venom.

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Citations

May 10, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M Sebastin SanthoshK S Girish
Mar 3, 2015·Toxicon : Official Journal of the International Society on Toxinology·K SunithaK S Girish
Jun 4, 2014·Journal of Biochemical and Molecular Toxicology·Abdulrahman K Al AsmariKitab E Al Otaibi
Oct 20, 2006·Reviews in Medical Virology·Subrat Kumar PandaShagufta Rehman
Apr 26, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·David Meléndez-MartínezLuis Fernando Plenge-Tellechea
Jul 5, 2017·Experimental and Therapeutic Medicine·Yazeed A Al-SheikhMourad A M Aboul-Soud
Jul 13, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Jamel El-BennaPham My-Chan Dang
Jul 21, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohamed A Abdel-RahmanPeter N Strong

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