Time course of microvascular resistance of the infarct and noninfarct coronary artery following an anterior wall acute myocardial infarction

The American Journal of Cardiology
Matthijs BaxJan J Piek

Abstract

Previous studies have suggested that coronary flow velocity reserve (CFVR) in the early phase of acute myocardial infarction (AMI) is abnormal in infarcted and remote regions. This study determined the coronary microvascular resistance of infarct-related arteries (IRAs) and non-IRAs during AMI and at follow-up in patients who were treated with primary percutaneous intervention. In 73 patients with a first anterior wall AMI, baseline and minimal microvascular resistance in IRAs and non-IRAs immediately after reperfusion and at 1-week and 6-month follow-up were calculated as the ratio of mean transvascular pressure gradient to mean baseline and to adenosine-induced hyperemic blood flow velocity, respectively. CFVR in IRAs increased from 1.6 +/- 0.4 after reperfusion to 1.9 +/- 0.5 at 1 week and to 3.0 +/- 0.8 at 6 months (p <0.0001) and in non-IRAs from 2.4 +/- 0.5 to 2.7 +/- 0.6 at 1 week to 3.3 +/- 0.6 at 6 months (p <0.0001). Minimal microvascular resistance in IRAs and non-IRAs (3.2 +/- 1.7 and 2.2 +/- 0.6 mm Hg/second/cm, respectively) decreased significantly at follow-up (2.0 +/- 0.6 and 1.7 +/- 0.6 mm Hg/second/cm at 1 week and 1.8 +/- 0.6 and 1.8 +/- 0.7 mm Hg/second/cm at 6 months, respectively). After correction for rat...Continue Reading

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Citations

Apr 24, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Froukje NolteJan J Piek
Feb 21, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M RemmelinkJ Baan
Sep 27, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Martijn A van LavierenJan J Piek
Nov 27, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Maurice RemmelinkJan Baan
Feb 14, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Guus A de WaardNiels van Royen
Jun 21, 2018·Expert Review of Cardiovascular Therapy·Fabio MangiacapraEmanuele Barbato
Aug 1, 2013·Circulation. Cardiovascular Interventions·Tim P van de HoefMartijn Meuwissen
May 21, 2010·Circulation. Cardiovascular Interventions·Murat SezerSabahattin Umman
Sep 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Maurice RemmelinkJan Baan
Jun 26, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Bart-Jan VerhoeffMaria Siebes
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Jan 19, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M A van LavierenJ J Piek
Jun 27, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jian WuYunzeng Zou
May 27, 2020·European Heart Journal. Acute Cardiovascular Care·Martijn A van LavierenJan J Piek
Feb 21, 2021·European Heart Journal. Acute Cardiovascular Care·Martijn A van LavierenJan J Piek
May 23, 2020·JACC. Cardiovascular Interventions·Troels ThimMichael Maeng

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