Time course of onset of sensitization to common and occupational inhalants in apprentices

The Journal of Allergy and Clinical Immunology
Bich NguyenD Gautrin

Abstract

Incident sensitization to common allergens in the setting of sensitization to an occupational allergen has not been described. Our aim was to determine the risk and timing of development of sensitization to common allergens in subjects with incident sensitization to a work-related allergen. Data from a cohort of 769 apprentices in animal-health technology, pastry making, and dental hygiene were used. Skin prick tests to work-related allergens (laboratory animal, flour, and latex) and common allergens (mites, molds, pets, and pollen) were administered at baseline and at up to 3 subsequent annual visits. Risk ratios (RRs) and 95% CIs were calculated. Eighty-three subjects had sensitization to a work-related allergen. Four (4.8%) subjects became sensitized to common and then occupational allergens. Nine (10.8%) subjects had sensitization to a common allergen after sensitization to a work-related allergen. In 20 (24.1%) subjects new sensitizations to specific and common allergens were detected simultaneously. Fifty subjects remained free from new sensitization to occupational allergen during development of sensitization to common allergens. An increased risk of development of sensitization to molds (RR = 3.49) and pets (RR = 2.51) ...Continue Reading

Citations

Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Jan 27, 2006·American Journal of Respiratory and Critical Care Medicine·George PiligianElizabeth Wilk-Rivard
Jan 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H-W ParkS-H Cho
Mar 5, 2009·Respiratory Research·Gianna MoscatoUNKNOWN European Academy of Allergology and Clinical Immunolgy
Feb 15, 2013·Journal of Occupational Medicine and Toxicology·Xaver Baur, Liubov Barbinova
Oct 28, 2003·American Journal of Respiratory and Critical Care Medicine·Karim MaghniJean-Luc Malo
Apr 4, 2006·Environmental Health Perspectives·MaryJane K SelgradeKarin B Yeatts
Apr 5, 2011·Allergy, Asthma & Immunology Research·Hyun Jung JinHae-Sim Park
Sep 2, 2016·Deutsches Ärzteblatt International·Katja RadonFranziska Ruëff
May 25, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Samuel DorevitchJeffrey D Fortman

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