PMID: 7087394Jul 1, 1982Paper

Time course of peroxisome biogenesis during adaptation to mild hyperthyroidism in rat liver: a morphometric/stereologic study by electron microscopy

Laboratory Investigation; a Journal of Technical Methods and Pathology
B Fringes, A Reith

Abstract

The subcellular reaction pattern of the peroxisome compartment in rat liver cells has been studied after thyroid hormone administration for 1, 3, 5, 8, and 15 days (20 micrograms of 3, 3', 5'-triiodothyronine (T3) per 100 gm. of body weight per day). Mild hyperthyroidism caused by T3 resulted in the enlargement of the peroxisome volume fraction. This was achieved exclusively by an increase in organelle number (31 x 10(9) +/- 1.5 x 10(9) per 1 cu. cm. per cu. cm. of cytoplasm in controls), since the average organelle volume (0.27 +/- 0.02 cu. micrometer in controls) was simultaneously reduced. The remodeling of the peroxisome compartment was, for the most part, completed on day 3 and consisted of a first preliminary doubling of peroxisome numbers after 1 day, followed by a second doubling on day 3. Each doubling was accompanied by a one-third reduction in the average organelle volume. Peroxisome biogenesis due to T3 resulted in (1) the formation of microperoxisomes, consisting of small profiles, lacking the core-structure and (2) an increase of peroxisomes arranged in clusters. Cluster types with two to three profiles appeared from the beginning of biogenesis, whereas clusters with four or more profiles were mostly observed at t...Continue Reading

References

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Citations

Oct 1, 1984·Archives of Toxicology·A M MitchellC R Elcombe
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·F RoelsJ M Saudubray
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·D De CraemerF Roels
Feb 4, 1992·Biochemical Pharmacology·S Green
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P BentleyH J Wiegand
Jan 1, 1991·Journal of Inherited Metabolic Disease·F RoelsD De Craemer
Jan 1, 1995·Journal of Inherited Metabolic Disease·I KerckaertG Van Limbergen
Jan 1, 1995·Journal of Inherited Metabolic Disease·D De Craemer
Sep 30, 1999·Environmental Health Perspectives·J Youssef, M Badr
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·F GogliaA Barletta
Dec 28, 2004·Ageing Research Reviews·Jihan A Youssef, Mostafa Z Badr
Nov 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T IkedaT Suga
Feb 8, 2003·American Journal of Respiratory and Critical Care Medicine·Antonia FehrenbachHeinz Fehrenbach
Apr 1, 1987·Environmental Health Perspectives·D E HintonR S McCuskey

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