PMID: 6404875Mar 1, 1983Paper

Time course of posthyperventilation breathing in humans depends on alveolar CO2 tension

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
H Folgering, M Durlinger

Abstract

The time course of the decrease in ventilation immediately after 1 min of voluntary isocapnic hyperventilation was studied in eight healthy subjects. The hyperventilation tests were done at three different levels of alveolar CO2 tension (PACO2), and at each PACO2 level with a fixed respiratory frequency and with a freely chosen (increased) frequency. The time constant of the decrease in ventilation after free-frequency hyperventilation was inversely related to the PACO2, with a regression equation of tau 1 (s) = 78.6 - 1.2 PACO2. After the fixed-frequency hyperventilation, the time constant of the decrease in ventilation was virtually zero and independent of PACO2. These results do not agree with earlier findings in anesthetized animals. The fact that hypocapnia increases the excitability of neurons might explain the findings. The extreme respiratory afterdischarge phenomenon in hypocapnic patients suffering from the hyperventilation syndrome is consistent with the outcome of this study.

Citations

Jan 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dennis JensenDenis E O'Donnell
Dec 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan E PrestonJohn T Fisher
Apr 1, 1986·European Journal of Pediatrics·H Folgering, J Boon
Nov 24, 2004·Journal of Applied Physiology·Dennis JensenGregory A L Davies
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·J H Mateika, J Duffin
Jun 1, 1986·Clinical Otolaryngology and Allied Sciences·E J TheunissenH T Folgering

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.