Time course of prostatic edema post permanent seed implant determined by magnetic resonance imaging

Brachytherapy
Ron SlobodaDon Yee

Abstract

To quantify the time course of postimplant prostatic edema magnitude and spatial isotropy using serial magnetic resonance imaging (MRI). Forty patients with histologic diagnosis of prostate cancer received an iodine-125 seed implant (Day 0) and consented to 1.5-T MRI on Days -1, 0, 14, and 28. Seeds of strength 0.39mCi were placed in a modified peripheral loading pattern to deliver 145Gy to the target volume. MR images consisted of 3-4mm thick axial slices with no gap. The image sets were anonymized and randomized to minimize contouring bias, then contoured by a single radiation oncologist. Contours were reoriented about their center of mass to align the prostate long axis with the superior-inferior (S-I) direction; prostate volumes and dimensions in the left-right (L-R), anterior-posterior (A-P), and S-I directions through the center of mass were calculated. The average relative edema volume was 1.18±0.14 (1standard deviation) on Day 0 and 1.01±0.15 on Day 30. Between Days 0 and 30, the edema resolved linearly with time on average. Average relative edema dimensions on Day 0 in the L-R, A-P, and S-I directions were 1.01±0.07, 1.11±0.09, and 1.08±0.13, respectively. As measured using MRI, the average edema magnitude for our stud...Continue Reading

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Citations

May 5, 2012·Journal of Medical Physics·Ron S SlobodaD M-C Liu
May 15, 2013·Brachytherapy·Noha JastaniyahNawaid Usmani
Apr 25, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Loredana G Marcu, Raghu Gowda
Aug 6, 2011·Brachytherapy·Hendrik WestendorpCarel J Hoekstra
Jun 7, 2011·International Journal of Radiation Oncology, Biology, Physics·Eugene ChungPatrick W McLaughlin
Jul 16, 2010·International Journal of Radiation Oncology, Biology, Physics·Nawaid UsmaniTara Monajemi
Jan 4, 2015·Australasian Physical & Engineering Sciences in Medicine·Kent J GregoryGiovanni Bibbo
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anna M DinklaArjan Bel
Jul 15, 2011·Physics in Medicine and Biology·Nacim BetrouniSerge Mordon
Dec 25, 2015·Journal of Applied Clinical Medical Physics·Sandeep K DhanesarRajat J Kudchadker

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