PMID: 9551751Apr 29, 1998Paper

Time course of pulmonary artery pressure during sleep in sleep apnoea syndrome: role of recurrent apnoeas

The European Respiratory Journal
E SforzaC E Sullivan

Abstract

Recent results in animals have suggested that repetition of hypoxaemic stimuli may result in a progressive increase in pulmonary arterial pressure (Ppa). The purpose of the present study was to investigate the effects of recurrent obstructive apnoeas on Ppa. We have, therefore, examined the nocturnal trend of Ppa in seven obstructive sleep apnoea syndrome (OSAS) patients and in five snorers. Mean Ppa was measured before, at the start, at the end and after the selected apnoeas. The analysis was performed for each 1 h period for at least 7 h throughout the night on at least 10 randomly selected apnoeas per hour. In snorers, 100 randomly chosen values were measured during every hour of the night. In the morning after the nocturnal study, the Ppa responses to acute hypoxia and hypercapnia were measured. No Ppa changes throughout the 7 h were found during sleep in snorers [Ppa slope:-0.002+/-0.10 mmHg x h(-1)]. In OSAS patients a small but significant increase in Ppa throughout the night was noted, affecting the values before [Ppa slope: 0.7+/-0.16 mmHg x h(-1)], at the start of apnoea [Ppa slope: 0.530.1 mmHg x h(-1)] as well as at the end [Ppa slope: 0.44+/-0.08 mmHg x h(-1)] and in the postapnoeic period [Ppa slope: 0.55+/-0.1 mm...Continue Reading

Citations

Nov 26, 2009·Current Treatment Options in Cardiovascular Medicine·Andrew D CalvinVirend K Somers
Mar 3, 2009·Progress in Cardiovascular Diseases·Dimitar Sajkov, R Doug McEvoy
Sep 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D S HuiP K Li
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Apr 27, 2019·The European Respiratory Journal·Rodrigo SoriaStefano F Rimoldi
Sep 15, 2020·The International Journal of Cardiovascular Imaging·W WuestA Schmid
Sep 22, 2015·Current Opinion in Pulmonary Medicine·Milan Minic, Clodagh M Ryan

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