Time-course of recovery of dopamine neuron activity during reinnervation of the denervated striatum by fetal mesencephalic grafts as assessed by in vivo voltammetry

Experimental Brain Research
C ForniA Nieoullon

Abstract

In vivo voltammetry was used to monitor dopamine (DA) neuron activity during the course of reinnervation of the initially denervated caudate-putamen by grafted mesencephalic neurons. Fetal DA neurons were implanted as a cell suspension into the depth of the caudate-putamen in adult 6-hydroxy-dopamine-lesioned recipient rats. Recordings were performed over a period of 2.5-4 months, starting within a week after transplantation, using chronically implanted surface-treated multifiber carbon electrodes. The voltammetric method used in this study has generated considerable discussion centred on the ability of the multifiber electrodes to measure DA alone in vivo, but the results of previous studies have led to the conclusion that changes in the voltammetric signal most probably reflect dopaminergic terminal activity. It seems therefore possible to follow the time-course of changes in the voltammetric signal amplitude during the process of dopaminergic reinnervation of the host striatum from the grafts. A 6-hydroxydopamine lesion of the mesostriatal dopamine pathway caused a substantial (greater than 80%) reduction of the voltammetric signal within 8-10 days, and the low residual signal remained essentially unchanged for time periods ...Continue Reading

Citations

Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
May 20, 1997·Brain Research. Developmental Brain Research·J ZhouG M Stern
Jul 1, 2008·Progress in Neurobiology·Tomas DeierborgPatrik Brundin
Jun 18, 1993·Brain Research·P J Sollars, G E Pickard
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·D F EmerichP R Sanberg
Aug 13, 2005·Neurobiology of Disease·Eleonora MariesKathy Steece-Collier
Jan 1, 1993·Reviews in the Neurosciences·C GagnonT Di Paolo
May 18, 2000·Nature Neuroscience·A Björklund, O Lindvall
Oct 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniella RylanderBarbara Picconi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.