Time course of rocuronium-induced neuromuscular block after pre-treatment with magnesium sulphate: a randomised study

Acta Anaesthesiologica Scandinavica
C CzarnetzkiM R Tramèr

Abstract

A previously published study suggested that pre-treatment with magnesium sulphate (MgSO(4)) had no impact on the speed of onset of rocuronium-induced neuromuscular block. We set out to verify this assumption. Eighty patients (18-60 years) were randomly allocated to MgSO(4) 60 mg/kg or placebo (saline). Study drugs were given intravenously for 15 min before induction of anaesthesia with propofol, sufentanil and rocuronium 0.6 mg/kg. Anaesthesia was maintained with a target-controlled propofol infusion. Neuromuscular transmission was measured using train-of-four (TOF)-Watch SX acceleromyography. Onset was analysed in 37 MgSO(4) and 38 saline patients, and recovery in 35 MgSO(4) and 37 saline patients. Onset time (to 95% depression of T1) was on average 77 [SD=18] s with MgSO(4) and 120 [48] s with saline (P<0.001). The total recovery time (DurTOF0.9) was on average 73.2 [22] min with MgSO(4) and 57.8 [14.2] min with saline (P<0.003). The clinical duration (Dur25%) was on average 44.7 [14] min with MgSO(4) and 33.2 [8.1] min with saline (P<0.0002). The recovery index (Dur25-75%) was on average 14.0 [6] min with MgSO(4) and 11.2 [5.2] min with saline (P<0.02). The recovery time (Dur25%TOF0.9) was on average 28.5 [11.7] min with MgS...Continue Reading

References

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Jul 20, 2007·Acta Anaesthesiologica Scandinavica·T Fuchs-BuderUNKNOWN 8th International Neuromuscular Meeting
Mar 26, 2009·Acta Anaesthesiologica Scandinavica·M Eikermann, L S Rasmussen

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Citations

Nov 28, 2012·International Journal of Obstetric Anesthesia·C Dean, J Douglas
Mar 1, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Michael S Lord, John G T Augoustides
Jul 11, 2012·Korean journal of anesthesiology·Sang-Hun KimKi-Tae Jung
Jan 21, 2012·Acta Anaesthesiologica Scandinavica·C CzarnetzkiM R Tramèr
Jan 15, 2015·Acta Anaesthesiologica Scandinavica·C UnterbuchnerT Metterlein
Mar 3, 2011·Anesthesiology·Susanne HerroederMarkus W Hollmann
Sep 18, 2018·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Cong Chen, Rui Tao
Nov 10, 2013·European Journal of Anaesthesiology·Ignacio Armendáriz-BuilJorge Vera-Bella
Dec 25, 2012·European Journal of Anaesthesiology·Ho S Moon, Jin Y Chon
Jun 22, 2012·European Journal of Anaesthesiology·Younes AissaouiMohammed Boughalem
May 21, 2019·Frontiers in Pharmacology·Ismar Lima CavalcantiNubia Verçosa
Jul 13, 2019·Current Pharmaceutical Design·Deepak AgarwalEhab Farag
Jul 29, 2020·Nutrients·Hyun-Jung ShinSang-Hwan Do
Jul 28, 2021·The Journal of International Medical Research·Haiyan SunRen Liao
Aug 18, 2021·Brazilian Journal of Anesthesiology·Carlos Eduardo David de AlmeidaNorma Sueli Pinheiro Modolo

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