PMID: 9437802Jan 23, 1998Paper

Time course of stomach mineralization, plasma, and urinary changes after a single intravenous administration of gadolinium(III) chloride in the male rat

Toxicologic Pathology
J ReesE Harpur

Abstract

In a previous experiment it was reported that the intravenous administration of gadolinium chloride (GdCl3) to rats results in a discrete band of interstitial mineralization in the fundic glandular mucosa of the stomach. To investigate the time course for the development of this lesion and its relationship to plasma calcium and phosphate concentrations, 2 experiments were carried out in male Sprague-Dawley rats given a single intravenous dose of 0.07 mmol/kg GdCl3. Plasma calcium and phosphate concentrations approximately doubled between 30 min and 12 hr postdose but had regressed back to near normal values by 24 hr. However, there were no observable clinical signs in treated animals. Histologically, there was progressive mineralization of the lamina propria of the neck region of the fundic glands from 6 hr postdose, forming a distinctive mineral band by 12 hr postdose. At 7 and 14 days postdose the mineral deposits were accompanied by mucous cell hyperplasia, interstitial fibrosis, and a very sparse infiltration of inflammatory cells. By 56 days postdose only occasional mineral deposits remained. Transmission electron microscopy showed mineral first nucleated on collagen in the interstitium, but there was no evidence of cell n...Continue Reading

References

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May 1, 1992·Bone and Mineral·S Y AliC A Scotchford
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Sep 1, 1996·Toxicologic Pathology·A J WassermanS K Durham
May 1, 1997·Toxicologic Pathology·A J SpencerE Harpur

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Citations

Aug 31, 2013·Cell Biology and Toxicology·G R Betton
Jan 13, 1998·Vision Research·B A Olshausen, D J Field
Apr 21, 2001·Cardiovascular Drug Reviews·L C AddingL E Gustafsson
Dec 29, 1998·Human & Experimental Toxicology·A SpencerE Harpur

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