Time-course of upper respiratory tract viral infection and COPD exacerbation

The European Respiratory Journal
Daiana StolzMichael Tamm

Abstract

Viral respiratory tract infections have been implicated as the predominant risk factor for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). We aimed to evaluate, longitudinally, the association between upper respiratory tract infections (URTI) caused by viruses and AECOPD.Detection of 18 viruses was performed in naso- and orοpharyngeal swabs from 450 COPD patients (Global Initiative for Chronic Obstructive Lung Disease stages 2-4) who were followed for a mean of 27 months. Swabs were taken during stable periods (n=1909), at URTI onset (n=391), 10 days after the URTI (n=356) and during an AECOPD (n=177) and tested using a multiplex nucleic acid amplification test.Evidence of at least one respiratory virus was significantly higher at URTI onset (52.7%), 10 days after the URTI (15.2%) and during an AECOPD (38.4%), compared with the stable period (5.3%, p<0.001). During stable visits, rhinovirus accounted for 54.2% of all viral infections, followed by coronavirus (20.5%). None of the viruses were identified in two consecutive stable visits. Patients with a viral infection at URTI onset did not have a higher incidence of exacerbation than patients without viral infection (p=0.993). Τhe incidence of any viral in...Continue Reading

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Citations

Jun 6, 2020·Expert Review of Respiratory Medicine·John CafferkeyPatrick Mallia
Aug 23, 2020·Respiratory Research·Julia SanchezDaiana Stolz
Jul 9, 2020·Frontiers in Cellular and Infection Microbiology·Haleh GanjianUmadevi Sajjan
Jan 12, 2021·Indian Journal of Clinical Biochemistry : IJCB·Himani RathiManisha Naithani
Dec 4, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Alexander G MathioudakisAntonio Spanevello
Jun 3, 2021·International Journal of Molecular Sciences·Belinda CampJens Schreiber
Sep 21, 2021·Seminars in Respiratory and Critical Care Medicine·Etienne de Montmollin, Jean-François Timsit

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