Time-course study of adipose tissue fatty acid composition during mammary tumor growth in rats with controlled fat intake

Nutrition and Cancer
C LhuilleryG Durand

Abstract

Previous work in breast cancer patients has indicated an inverse relationship between the risk of relapse and the alpha-linolenic acid (18:3n-3) level in adipose breast tissue. To determine whether low alpha-linolenic levels in patients with aggressive breast cancer resulted from lower 18:3n-3 dietary intake and/or increased metabolism of stored 18:3n-3, we analyzed the fatty acid composition of mammary adipose tissue during tumor growth in a rat model of mammary carcinogenesis. Rats were fed a diet containing 10% fat as rapeseed oil (in which 9% of total fatty acids is 18:3n-3). one-half of the rats received an injection of nitrosomethylurea (NMU) to initiate mammary tumors. In control and NMU-treated groups, three to five animals were sacrificed every three weeks during the five-month experimental time. tumor growth was followed by weekly palpation of the animals and by the measure of total tumor mass and number in sacrificed rats. Mammary tumor and adipose tissues were sampled in sacrificed rats. We found that although mammary adipose tissue fatty acid profile changed throughout the experiment, there was no difference in fatty acid profile between control and NMU-treated rats of the same age. In the NMU-treated group, 18:3n-...Continue Reading

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Citations

Oct 26, 2005·Breast Cancer Research and Treatment·N V RajeshkumarAnil Gulati
Mar 23, 2012·Breast Cancer Research and Treatment·Karine MahéoCaroline Goupille
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Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Séverine ColasPhilippe Bougnoux

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