PMID: 6152899Oct 1, 1984

Time course study of L-tyrosine aminotransferase induction in rat liver cell lines

Cell Biology and Toxicology
M ChessebeufP Padieu


The enhancement of L-tyrosine aminotransferase activity by dexamethasone, an exclusive function of the liver, was serially measured at different passages of eight rat liver epithelial cell lines initiated and continuously grown in either a serum-supplemented medium or a serum-free medium. The enzyme basal activity was found to be 5.4 +/- 1.8 mU for cell lines in serum and 6.8 +/- 3.4 mU for cell lines without serum. Under the influence of dexamethasone (10(-6) mol/l for 5 hours) this basal level could be increased up to 2.9 fold in the presence of serum and 2.5 fold in its absence when investigations were carried out at early passages. During the following subcultures the induction ratio gradually declined and scarcely any induction could be detected after the 15th passage for cells grown in serum and after the 25th passage for cell lines grown without serum.


Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A E SiricaH C Pitot
Aug 20, 1976·Cell and Tissue Research·B PerisselP Malet
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E B ThompsonJ F Curran
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·T D Gelehrter, G M Tomkins
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·T D Gelehrter, G M Tomkins
Apr 15, 1981·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Oct 1, 1984·Journal of Steroid Biochemistry·J DesgrèsP Padieu
Apr 1, 1981·Cell Biology International Reports·M ChessebeufP Padieu
May 1, 1980·Cell Biology International Reports·M F ExilieP Padieu
Oct 1, 1957·Biochimica Et Biophysica Acta·E C LIN, W E KNOX

Related Concepts

Enzyme Induction
Tyrosine Aminotransferase
Rats, Laboratory

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