PMID: 8983869Oct 1, 1996Paper

Time course study of oxidative stress in aorta and heart of diabetic rat

Clinical Science
R KakkarK Prasad

Abstract

1. Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. In the present study, we investigated the lipid peroxide level [thiobarbituric acid-reactive substances (TBARS)] and activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) in aorta, heart and blood of control and streptozotocin-induced diabetic rats at various stages of development of diabetes (0 to 6 weeks). 2. There was no change in the TBARS levels of aorta, heart and blood in the control group. A significant (P < 0.05) increase in TBARS levels of aorta, heart and blood was observed in the diabetic group. 3. There were no significant changes in the activities of superoxide dismutase, catalase and glutathione peroxidase in the aorta, heart and blood of control rats at all time intervals. In the diabetic group, there was a significant (P < 0.05) increase in the activity of superoxide dismutase and glutathione peroxidase in aorta from the fourth week onwards while the activity of catalase increased at all time intervals. In the heart of diabetic rats, the activity of total superoxide dismutase and Cu-Zn-superoxide dismutase increased significantly (P < 0.05) from the second week o...Continue Reading

Citations

Nov 5, 2002·Cell Biochemistry and Function·Tuğba HünkarUNKNOWN Antioxidants in Diabetes-Induced Complications (ADIC) Study Group
Feb 13, 2003·Cell Biochemistry and Function·Ozlem Yildirim, Zeliha Büyükbingöl
Apr 9, 2008·Journal of Diabetes and Its Complications·Alireza ShirpoorKamal Khademvatani
Aug 21, 2010·The Journal of Pharmacy and Pharmacology·Neeti JainMohammed Ali
Sep 24, 2004·European Journal of Pharmacology·Kübra PaskalogluGül Ayanğolu-Dülger
Mar 27, 2007·Journal of Pharmacological Sciences·Kazumi IwataChihiro Yabe-Nishimura
Jul 4, 2001·The Journal of Laboratory and Clinical Medicine·K Prasad
Oct 26, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K L De AngelisM C Irigoyen
Jun 15, 2006·Izvestiia Akademii nauk. Seriia biologicheskaia·N I VenediktovaIu G Kaminskiĭ
Dec 19, 2003·International Journal of Toxicology·Mary OtsyulaJohn B Watkins
Nov 18, 2000·Journal of Biochemical and Molecular Toxicology·F M RauscherJ B Watkins
Jul 25, 2013·International Journal of Molecular Sciences·Kiyoshi KikuchiEiichiro Tanaka
Sep 14, 2017·Environmental Science and Pollution Research International·Carolina Falcão XimenesIvanita Stefanon
Sep 30, 2006·Journal of Biochemical and Molecular Toxicology·Zipporah T KamurenJohn B Watkins
Sep 17, 2013·Diabetes/metabolism Research and Reviews·Manisha A ModakSaroj S Ghaskadbi
Jul 7, 2011·Hypertension·Heinrich E LobDavid G Harrison
May 12, 2010·Cardiovascular Toxicology·Guy Vassort, Belma Turan
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Farid NakhoulNitza Mirsky
May 1, 2015·Clinical Science·Elyse Di MarcoJudy B de Haan
May 25, 2006·The Biochemical Journal·Neslihan ToyranFeride Severcan
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Farzad EbrahimiAhmad Reza Dehpour
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M ZanettiT O'Brien
Mar 27, 2019·Canadian Journal of Physiology and Pharmacology·Naranjan S DhallaParamjit S Tappia
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Nov 24, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·A GumieniczekM Nieradko

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