PMID: 2109153Mar 1, 1990Paper

Time-courses of the appearance/disappearance of nuclear androgen + receptor complexes in the brain and adenohypophysis following testosterone administration/withdrawal to castrated male rats: relationships with gonadotropin secretion

Journal of Steroid Biochemistry
L C Krey, Marilyn Y McGinnis

Abstract

We characterized the temporal dynamics of brain and pituitary cell nuclear androgen receptor binding and serum androgen and gonadotropin levels associated with the implantation and removal of testosterone (T)-filled Silastic capsules into performed s.c. flank pouches of castrated, awake male rats. These capsules produced serum T levels in the physiologic range. The number of cell nuclear androgen + receptor complexes, as measured in an exchange assay using [3H]R1881, increased 15-fold at 0.5 h after capsule insertion in the HPAS (combined hypothalamus, preoptic area, amygdala and septum) and anterior pituitary gland, but then showed a second progressive rise within the next 8 h. This pattern suggests that T exerts an initial action in the tissues to alter the affinity and/or number of available androgen receptors. There was a lag time of 2-4 h to the first indication of negative feedback suppression of LH secretion. Serum LH levels declined only slightly at 4 h after capsule insertion but continued to fall thereafter, reaching undetectable values by 24 h. In contrast, serum FSH levels declined only slightly after 24 h of T exposure. After removal of the T capsules, serum T levels declined to castrate values within 2 h at which ...Continue Reading

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Citations

Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·M A Charles, M Y McGinnis
Jan 1, 1996·Brain Research. Molecular Brain Research·S M DrenglerK J Jones
Jan 1, 1995·Brain Research Bulletin·M Y McGinnis, W H Yu
Apr 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C E Roselli, T A Fasasi
Oct 5, 2013·General and Comparative Endocrinology·Kimberly A RosvallEllen D Ketterson
Apr 16, 2003·Hormones and Behavior·Shannon M Harding, Marilyn Y McGinnis
Jun 14, 2002·Physiology & Behavior·Marilyn Y McGinnisBernard P Possidente
Oct 22, 2003·Physiology & Behavior·Marilyn Y McGinnis, M Vakulenko
Apr 12, 2003·Psychoneuroendocrinology·Alonso Fernandez-GuastiGabriela Rodríguez-Manzo
Nov 23, 2005·Behavioral Neuroscience·Shannon M Harding, Marilyn Y McGinnis
Mar 15, 2012·Neuroendocrinology·Rebecca L CunninghamMarilyn Y McGinnis
Jan 22, 2010·European Journal of Endocrinology·Johannes D VeldhuisPaul Y Takahashi
Apr 13, 2011·Epilepsy & Behavior : E&B·Sabrina SuffrenOrrin Devinsky
Nov 11, 2008·Hormones and Behavior·David J PiekarskiIrving Zucker
May 15, 2007·Hormones and Behavior·Elaine M Hull, Juan M Dominguez
Dec 4, 2008·The Journal of Comparative Neurology·Di WuAndrea C Gore
Jan 1, 1996·Brain Research Bulletin·M E Vagell, M Y McGinnis
Jun 5, 2004·Physiology & Behavior·Shannon M Harding, Marilyn Y McGinnis
Apr 11, 2006·Pharmacology, Biochemistry, and Behavior·Daniel W Wesson, Marilyn Y McGinnis
Sep 6, 2011·Brain Research·Monica L AndersenSergio Tufik
Sep 24, 2016·Neuropeptides·Yoshikage Muroi, Toshiaki Ishii
Dec 7, 2000·Journal of Neurobiology·W H Yu, M Y McGinnis
Mar 14, 2018·Hormones and Behavior·Tiffany Y Yang, Nu-Chu Liang
Jun 18, 2021·Science Advances·Stephen X ZhangMichael A Crickmore

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