Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments

International Journal of Environmental Research and Public Health
Francisco Sánchez-Bayo, Henk A Tennekes

Abstract

Our mechanistic understanding of the toxicity of chemicals that target biochemical and/or physiological pathways, such as pesticides and medical drugs is that they do so by binding to specific molecules. The nature of the latter molecules (e.g., enzymes, receptors, DNA, proteins, etc.) and the strength of the binding to such chemicals elicit a toxic effect in organisms, which magnitude depends on the doses exposed in a given timeframe. While dose and time of exposure are critical factors determining the toxicity of pesticides, different types of chemicals behave differently. Experimental evidence demonstrates that the toxicity of neonicotinoids increases with exposure time as much as with the dose, and therefore it has been described as time-cumulative toxicity. Examples for aquatic and terrestrial organisms are shown here. This pattern of toxicity, also found among carcinogenic compounds and other toxicants, has been ignored in ecotoxicology and risk assessments for a long time. The implications of the time-cumulative toxicity of neonicotinoids on non-target organisms of aquatic and terrestrial environments are far reaching. Firstly, neonicotinoids are incompatible with integrated pest management (IPM) approaches and secondly ...Continue Reading

References

Apr 21, 2001·Journal of Agricultural and Food Chemistry·M TomizawaJ E Casida
Nov 9, 2001·Environmental Toxicology and Chemistry·S SuchailL P Belzunces
Jan 29, 2002·Toxicology·David M SoderlundMyra L Weiner
Nov 22, 2005·Environmental Science & Technology·Tjalling Jager, Sebastiaan A L M Kooijman
Aug 11, 2007·Archives of Environmental Contamination and Toxicology·Tham C HoangStephen J Klaine
Sep 8, 2007·Environmental Science & Technology·Roman AshauerColin D Brown
Mar 20, 2008·Environmental Toxicology and Chemistry·Mikhail A Beketov, Matthias Liess
Aug 21, 2008·Pest Management Science·Peter Jeschke, Ralf Nauen
Dec 18, 2008·Ecotoxicology·Francisco Sánchez-Bayo
Apr 15, 2010·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ruth MüllerSabine Hilt
Jun 23, 2010·Journal of Agricultural and Food Chemistry·Peter JeschkeAlfred Elbert
Jul 27, 2010·Bulletin of Environmental Contamination and Toxicology·Paolo TremoladaMarco Vighi
Oct 6, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tjalling Jager, Chris Klok
Feb 28, 2013·Environmental Toxicology and Chemistry·Ivo RoessinkPaul J Van den Brink
May 8, 2013·PloS One·Tessa C Van DijkJeroen P Van der Sluijs
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mikhail A BeketovMatthias Liess
Aug 6, 2013·Ecotoxicology and Environmental Safety·Michiel A DaamMaria José Cerejeira
Jun 1, 1996·Ecotoxicology·M C Newman, J T McCloskey
Nov 30, 2013·Environmental Toxicology and Chemistry·Oleksandra IerominaMartina G Vijver
Mar 5, 2014·Environmental Science & Technology·Gaël CharpentierMartine Decoville
Jun 19, 2014·Environmental Science and Pollution Research International·David GibbonsPierre Mineau
Jul 6, 2014·Scientific Reports·Gary RondeauNicolas Desneux
Sep 17, 2014·Environmental Science and Pollution Research International·L W PisaM Wiemers
Sep 23, 2014·Environmental Science and Pollution Research International·N Simon-DelsoM Wiemers
Dec 3, 2014·Environment International·Christy A MorrisseyKarsten Liber
Feb 25, 2015·Environmental Toxicology and Pharmacology·Pelin UğurluElif İpek Satar
Oct 1, 2015·Environmental Toxicology and Chemistry·Paul J Van den BrinkIvo Roessink
Apr 20, 2016·Ecotoxicology·Abdulrahim T Alkassab, Wolfgang H Kirchner

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Citations

Jun 28, 2020·Communications Biology·Daniel SchläppiPeter Neumann
Aug 9, 2020·International Journal of Environmental Research and Public Health·Chao ZhangGiovanna Di Nardo
Jan 13, 2021·Scientific Reports·Lode K J VandammePaulo R F Rocha

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