Time delay for arrival of MR contrast agent in collateral-dependent myocardium

IEEE Transactions on Medical Imaging
M Jerosch-HeroldRavi Teja Seethamraju

Abstract

An analysis of the kinetics of myocardial contrast enhancement is an important component of myocardial perfusion studies. The contrast enhancement can be modeled by a linear time-invariant system, and the myocardial impulse response, calculated by deconvolution of the measured tissue response with an arterial input, gives a direct estimate of myocardial blood flow. In this paper, we analyze the effects of delays in the contrast enhancement, that occur in collateral-dependent myocardium, where the tracer reaches the tissue region only through branches from other coronary arteries that form natural bypass vessels. We investigate how the delayed arrival of tracer alters the myocardial impulse response. Model-independent deconvolution is applied to determine the lag between arterial input and tissue enhancement. Experimental data in a porcine model of collateral development indicate that the delayed arrival of an injected tracer, measured at rest, is a useful marker to identify collateral-dependent myocardium, and predict its flow capacitance.

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May 30, 2002·Medical Physics·Michael Jerosch-HeroldRavi Teja Seethamraju
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Citations

Sep 2, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Amit R PatelChristopher M Kramer
Nov 19, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nathan A PackJohn M Hoffman
Apr 30, 2009·Radiology·Marlies OostendorpWalter H Backes
Dec 26, 2015·European Heart Journal Cardiovascular Imaging·Amedeo ChiribiriEike Nagel
Apr 19, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thomas A GoldsteinJie Zheng
Jun 26, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nathan A Pack, Edward V R DiBella
Mar 11, 2009·IEEE Transactions on Medical Imaging·Volker J SchmidGuang-Zhong Yang
May 12, 2012·IEEE Transactions on Bio-medical Engineering·Gilion HautvastEike Nagel
Mar 28, 2006·Seminars in Ultrasound, CT, and MR·Michael Jerosch-HeroldNorbert Wilke
Jun 13, 2009·JACC. Cardiovascular Imaging·Daniel C Lee, Nils P Johnson
Feb 13, 2013·Acta Radiologica·Einar HoppHans-Jørgen Smith
Oct 30, 2018·Physics in Medicine and Biology·Judith LehnertClemens Elster

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