Time density curve analysis for C-arm FDCT PBV imaging

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
M Kamran, J V Byrne

Abstract

Parenchymal blood volume (PBV) estimation using C-arm flat detector computed tomography (FDCT) assumes a steady-state contrast concentration in cerebral vasculature for the scan duration. Using time density curve (TDC) analysis, we explored if the steady-state assumption is met for C-arm CT PBV scans, and how consistent the contrast-material dynamics in cerebral vasculature are across patients. Thirty C-arm FDCT datasets of 26 patients with aneurysmal-SAH, acquired as part of a prospective study comparing C-arm CT PBV with MR-PWI, were analysed. TDCs were extracted from the 2D rotational projections. Goodness-of-fit of TDCs to a steady-state horizontal-line-model and the statistical similarity among the individual TDCs were tested. Influence of the differences in TDC characteristics on the agreement of resulting PBV measurements with MR-CBV was calculated. Despite identical scan parameters and contrast-injection-protocol, the individual TDCs were statistically non-identical (p < 0.01). Using Dunn's multiple comparisons test, of the total 435 individual comparisons among the 30 TDCs, 330 comparisons (62%) reached statistical significance for difference. All TDCs deviated significantly (p < 0.01) from the steady-state horizontal-...Continue Reading

References

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Citations

Oct 19, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kyle P O'ConnorBradley N Bohnstedt

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Methods Mentioned

BETA
x-ray imaging

Software Mentioned

FSL
GraphPad
FMRIB library
Image J J
LOWESS
nordicICE
syngo Neuro PBV IR
FMRIB
FLIRT
FSL BET utility

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