Time dependence of estrogen receptor expression in human hearts

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Valentin LeibetsederCem Ekmekcioglu

Abstract

Transcriptional effects of estrogens are primarily mediated by the two nuclear estrogen receptors (ER), ERalpha and ERbeta. Both receptors are present in the vasculature and in the human heart and have been shown to act antiatherogenic and to be protective against the development of cardiac hypertrophy. The aim was to quantify ER mRNA expression in left ventricular specimens from patients with coronary heart disease (CHD, n=15) and dilated cardiomyopathy (CMP, n=38) and compare their levels with those from healthy heart donors (n=9). Additionally, a possible variation of ERmRNA expression in human hearts in respect to time of day was studied. mRNA expression of both ER receptors was detected by real-time PCR in all of the human specimens. There was no difference in the relative quantity of the receptors between CHD and CMP patients. However, control specimens showed significant lower levels of either receptor in the healthy myocardium (p<.001 each). Analyzing the time dependency of receptor expression with a cosinor analysis showed a significant 8-hour period rhythm for ERbeta in CMP- but no rhythm in CHD patients. Due to the low patient number, rhythmic analysis was not possible in controls. The increased ERalpha and ERbeta mR...Continue Reading

References

Oct 1, 1976·Molecular and Cellular Endocrinology·A HughesP W Jungblut
Jan 1, 1986·Chronobiology International·P K EagonT E Starzl
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·R H KarasM E Mendelsohn
Feb 5, 2000·Journal of Molecular Endocrinology·A H Taylor, F Al-Azzawi
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 12, 2003·Trends in Pharmacological Sciences·Jan-Ake Gustafsson
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Amanda M ShearmanDaniel Levy
Feb 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M-L Kortelainen, P Huttunen
Nov 10, 2004·Circulation·Johannes NordmeyerVera Regitz-Zagrosek
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shokoufeh MahmoodzadehVera Regitz-Zagrosek
Jul 13, 2006·Clinical Science·Shanhong LingKrishnankutty Sudhir
Nov 30, 2006·Pharmacological Reviews·Karin Dahlman-WrightJan-Ake Gustafsson
Jun 15, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·A T HenttonenS T Nikkari
Sep 22, 2007·Current Opinion in Lipidology·Jean-François ArnalPierre Gourdy
Nov 14, 2008·Chronobiology International·Francesco PortaluppiMichael H Smolensky

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Citations

Jun 1, 2012·Archives of Toxicology·Katherine A Burns, Kenneth S Korach
Nov 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Monika Puzianowska-Kuźnicka
Jul 12, 2016·International Journal of Molecular Sciences·Ben-Shian HuangPeng-Hui Wang
Oct 29, 2014·American Journal of Physiology. Renal Physiology·Ben-Shian HuangPeng-Hui Wang
Jan 30, 2020·Frontiers in Endocrinology·Leanne GrobanSarah H Lindsey
Feb 10, 2021·GeroScience·Rakesh GurralaSarah H Lindsey

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