PMID: 6160550Sep 1, 1980Paper

Time dependence of unipolar cathodal and anodal strength-interval curves

Pacing and Clinical Electrophysiology : PACE
R MehraS Furman

Abstract

Following pacemaker electrode attachment, greater ventricular vulnerability to arrhythmias exists in an acutely ischemic ventricle with a unipolar anodal than cathodal stimulus falling on the T wave, due to the shorter refractory period exhibited by an anodal stimulus. In order to determine the relationship between anodal and cathodal refractory period at various times following endocardial electrode insertion, ventricular strength-interval curves were determined in nine dogs. With stable electrode position, serial measurements were made for a mean duration of 44 days. It was observed that during the first five days, the anodal refractory period was significantly shorter than cathodal, but within 15-20 days this relationship was reversed in all dogs. The longer anodal refractory period was observed up to the end of each study. These results suggest that due to shorter anodal refractory period, greater vulnerability to arrhythmias may occur with an anodal than cathodal stimulus in the initial 15-20 days following electrode insertion.

References

Jan 1, 1979·Pacing and Clinical Electrophysiology : PACE·D C AmundsonM Mosharrafa
Jul 1, 1977·American Heart Journal·S FurmanR Mehra
Jun 1, 1975·Journal of Immunological Methods·R P Siraganian
Aug 1, 1957·The American Journal of Physiology·P F CRANEFIELDA A SIEBENS

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Citations

Mar 20, 2013·Computational and Mathematical Methods in Medicine·Sunil M Kandel, Bradley J Roth
Jan 30, 2009·Journal of Cardiovascular Electrophysiology·J Paul Mounsey, Stephen B Knisley
Feb 13, 1999·Journal of Electrocardiology·B J RothJ P Wikswo
Aug 15, 1990·The American Journal of Cardiology·A B CurtisK Miller-Shifrin
Feb 15, 1989·The American Journal of Cardiology·G H BardyH L Greene
Mar 4, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Sunil M Kandel, Bradley J Roth
Oct 1, 1995·Pacing and Clinical Electrophysiology : PACE·A NataleM Akhtar
Sep 1, 1983·Pacing and Clinical Electrophysiology : PACE·G C TimmisS Gordon
May 1, 1983·Pacing and Clinical Electrophysiology : PACE·K BreivikH Engedal
Aug 24, 1999·Pacing and Clinical Electrophysiology : PACE·J A Bennett, B J Roth
Aug 1, 1996·Journal of Cardiovascular Electrophysiology·B J Roth

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